DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drongo and Smap2

DIOPT Version :9

Sequence 1:	NP_001162848.1	Gene:	drongo / 33263	FlyBaseID:	FBgn0020304	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_598477.2	Gene:	Smap2 / 69780	MGIID:	1917030	Length:	428	Species:	Mus musculus

Alignment Length:	404	Identity:	88/404 - (21%)
Similarity:	144/404 - (35%)	Gaps:	114/404 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KQDDKYLLALRELVASGTGSNRQCFDCGQKGPTYVNMTIGSFVCTRCSGVLRGL-TPPHRVKSIS 70
            |..|:|...|..|:..  ..|:.|.||..|||.:.:..||.|:|.||:|:.|.| ....||||::
Mouse     7 KDVDRYQAVLANLLLE--EDNKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVN 69

  Fly    71 MATFTQDEIDFLRSHGNELCAKTWLGLWDP------KRAVHQQEQRELMMDKYERKRYYLEPASP 129
            :..:||::|..::..||....:    |::.      :|..........:.||||:|: |::.:..
Mouse    70 LDQWTQEQIQCMQEMGNGKANR----LYEAYLPETFRRPQIDPAVEGFIRDKYEKKK-YMDRSLD 129

  Fly   130 LKSLANAVNLK---SSAPATNHTQNGHQNGYASIHLTPPAAQRTSANGLQKVANSSSNSSGKTSS 191
            :..|....:.|   .:.||...            .:.|...::......::.|.....||.|:::
Mouse   130 INVLRKEKDDKWKRGNEPAPEK------------KMEPVVFEKVKMPQKKEDAQLPRKSSPKSAA 182

  Fly   192 SISRPHYNHQNNSQNNNHDAFGLGGGLSSLNSAGSTSTGALSDTSSCASNGFGADCDFVADFGSA 256
            .:.               |..||...:            |.|..:|..||....|.|.:|...|.
Mouse   183 PVM---------------DLLGLDAPV------------ACSIANSKTSNALEKDLDLLASVPSP 220

  Fly   257 NIFDATSARSTGS-PAVSSVSSV----------GSSNGYAKVQPIRAAHLQQQQQLQQQLHQQQL 310
            :   :.|.::.|| |...|..||          ||               :.::..::||.:..:
Mouse   221 S---SVSRKAVGSMPTAGSAGSVPENLNLFPEPGS---------------KSEETGKKQLSKDSI 267

  Fly   311 LNGNGHQGTENFAD-FDHAPIYNA--VAPPTFNDWISDWSRRGFHDPFDDCDDSPPGARPP---A 369
            |:..|.|..:..|. ...||...|  .|.|:|                       ||..||   .
Mouse   268 LSLYGSQTPQMPAQAMFMAPAQMAYPTAYPSF-----------------------PGVTPPNSIM 309

  Fly   370 PAPAPAQVPAVSSP 383
            ....|..|..|:.|
Mouse   310 GGMVPPPVGMVAQP 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drongo	NP_001162848.1	ArfGap	15..126	CDD:279720	35/117 (30%)
Smap2	NP_598477.2	ArfGap	13..126	CDD:307528	35/119 (29%)
		Interaction with clathrin heavy chains	163..231		18/97 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..262		10/61 (16%)
		Med15	276..>416	CDD:312941	15/71 (21%)
		Interaction with PICALM. /evidence=ECO:0000269\|PubMed:16571680	339..428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900