DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drongo and ADAP2

DIOPT Version :9

Sequence 1:	NP_001162848.1	Gene:	drongo / 33263	FlyBaseID:	FBgn0020304	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	XP_024306599.1	Gene:	ADAP2 / 55803	HGNCID:	16487	Length:	403	Species:	Homo sapiens

Alignment Length:	206	Identity:	50/206 - (24%)
Similarity:	79/206 - (38%)	Gaps:	67/206 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KKQDDKYLLALRELVASGTGSNRQCFDCGQKGPTYVNMTIGSFVCTRCSGVLRGLTPPHRVKSIS 70
            ::::.|.||.|  |.|..|| |..|.|||...|.:.:..:|.|:|..|.||.|......||||:.
Human     4 RERNKKRLLEL--LRAPDTG-NAHCADCGAADPDWASYKLGIFICLNCCGVHRNFPDISRVKSVR 65

  Fly    71 MATFTQDEIDFLRSHGN-ELCAK----------------------TWLGLWDPKRAVHQQEQREL 112
            :..:....::|:..:|| .:.||                      .|:      ||  :.|:||.
Human    66 LDFWDDSIVEFMIHNGNLRVKAKFEARVPAFYYIPQANDCLVLKEQWI------RA--KYERREF 122

  Fly   113 MMD----------------------KYERKRYYLEPASPL---------KSLANAVNLKSSAPAT 146
            |.|                      ::.|:::.|.....|         ||....:::| ...||
Human   123 MADGETISLPGNREGFLWKRGRDNSQFLRRKFVLLAREGLLKYFTKEQGKSPKAVISIK-DLNAT 186

  Fly   147 NHTQN-GHQNG 156
            ..|:. ||.:|
Human   187 FQTEKIGHPHG 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drongo	NP_001162848.1	ArfGap	15..126	CDD:279720	37/155 (24%)
ADAP2	XP_024306599.1	ArfGap	8..126	CDD:307528	37/128 (29%)
		PH1_ADAP	133..241	CDD:270072	12/66 (18%)
		PH2_ADAP	255..362	CDD:241282
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810