DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drongo and Asap

DIOPT Version :9

Sequence 1:	NP_001162848.1	Gene:	drongo / 33263	FlyBaseID:	FBgn0020304	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	145/738 - (19%)
Similarity:	233/738 - (31%)	Gaps:	276/738 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NRQCFDCGQKGP-TYVNMTIGSFVCTRCSGVLRGLTPPH-RVKSISMATFTQDEIDFLRSHGNE- 88
            |.:|.|||.:.. |::::..|..||.:||||.|.|...| |::|:::...|...:...|:.||.
  Fly   439 NDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDNLTTANLLIARAMGNST 503

  Fly    89 ----LCAKTWLGLWDPKRAVHQQEQRELMMDKYERKRYYLEPASP-------------------- 129
                :.||  ||....:.....:|:.:.:..||..|||.:...|.
  Fly   504 LNDIMEAK--LGRGKLQHESSMEERYDFIRAKYVAKRYVMRTCSDDNDLRCDLEQAVVNADMSQL 566

  Fly   130 LKSLANAVNLKSSAPATN------HTQNGHQNGYASIHLTPPAAQRTSANGLQKVANSS------ 182
            |:..|...:|....|:::      |.....:.| :::|:.....|.....||.|..|.:
  Fly   567 LQVWAEGADLTCCLPSSDAGETALHLAVLREMG-STLHIVDFLIQNMPPKGLNKATNPAGLLDVT 630

  Fly   183 ------------------------------SNSSGKTSSSISRP--H-----------------Y 198
                                          .||..||:..|::.  |                 :
  Fly   631 GKNTALHLCALHDRRECMKLLLRSGADYELKNSQNKTALDIAKEMGHNSCRELIECAIKREKSAF 695

  Fly   199 NHQNNSQN-NNHD----------------------AFGLGGGLSSLNSAGSTSTGALSDTS---S 237
            :|.|...| .|.|                      :|. ||....|.|..||.....|.:|   :
  Fly   696 DHINTDWNLPNEDGSTDFSDDETVIDERKSRSRPPSFA-GGDSPVLRSRSSTCDSIQSSSSPIAN 759

  Fly   238 CASNGFGADCDFVADFGSANIFDATSAR---STGSPAVSSVSSV--------GSSNGYAKVQPIR 291
            |.|..|.......:...||    .||.:   |.|. .:.|.::|        |||...|..|.:|
  Fly   760 CPSRQFTLPSGLPSYTHSA----GTSPKQHISVGQ-YLGSATNVGGNGPGNGGSSPSSASSQSVR 819

  Fly   292 AAHLQQQQQLQQQLHQQQLLNGN--GHQGTENFADFDHAPIYNAVAPPTFNDWISDWSRRGFHDP 354
            ||        :..|:.|..|.|:  |.:.:.:.|:.      |::...|
  Fly   820 AA--------RNSLNMQSDLGGHVTGARKSTSTANM------NSLKKRT---------------- 854

  Fly   355 FDDCDDSPPGARPPAPAPAPAQVPAVSSP--LPTVREEPELAWNFWEDEMRIEAQEKESQTKQ-- 415
                          ||||.|..:.:.||.  ..|:...|..:.||  |...|.|...::|:..
  Fly   855 --------------APAPPPGTLGSASSSSFYGTLPHPPRHSQNF--DASDIRAINHKNQSLDVA 903

  Fly   416 ----PEL-----------GYSFSISTTTPLS---PSNPFLPYLVS---------EEQHRN----- 448
                |.|           ||.:.:|.....|   .:|..:|.:.:         |..:||
  Fly   904 YGTLPHLRSVESSPRGGGGYGYGVSQDPGGSGNGSNNSLMPAMTTFGHKRSPSGESLNRNIHLAG 968

  Fly   449 ---------------HPEKPSFSYSLF-----------------SSISNSSQEDQADDHEMNVLN 481
                           |.:|.:.:....                 .|||:..:...|...::...:
  Fly   969 AKLVLPPTGELPTLKHVDKSALTRPKIPPPGPPSEREISNGQSNESISSMDEGPVAPPRKLVNQS 1033

  Fly   482 ANFHDFFTWSAPLQNGHTTSPPKGGNAAMAPSEDRYAALKDLDEQLRELKASESATETPTPTSGN 546
            |||.|:.:|       ||.....||  .:..|.:...:..|.|.       ..|:.:.|:.|.|
  Fly  1034 ANFPDYESW-------HTDMDSSGG--GLDHSAESNVSSSDNDR-------LNSSPDNPSKTGG- 1081

  Fly   547 VQATDAFGGALNNNPNPFKGQQQ 569
                ...||..:.|     ||::
  Fly  1082 ----AGLGGKFHYN-----GQRR 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drongo	NP_001162848.1	ArfGap	15..126	CDD:279720	32/105 (30%)
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288
		PH_ASAP	302..410	CDD:270071
		ArfGap_ASAP	425..541	CDD:350063	32/103 (31%)
		Ank_2	554..662	CDD:403870	12/108 (11%)
		ANK repeat	586..622	CDD:293786	7/36 (19%)
		ANK repeat	624..662	CDD:293786	0/37 (0%)
		Ank_2	636..>693	CDD:403870	6/56 (11%)
		SH3_ASAP	1095..1149	CDD:212755	0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464135
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830