DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drongo and AGFG1

DIOPT Version :9

Sequence 1:	NP_001162848.1	Gene:	drongo / 33263	FlyBaseID:	FBgn0020304	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_001128659.1	Gene:	AGFG1 / 3267	HGNCID:	5175	Length:	584	Species:	Homo sapiens

Alignment Length:	762	Identity:	196/762 - (25%)
Similarity:	283/762 - (37%)	Gaps:	270/762 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AVVRKKQDDKYLLALRELVASGTGSNRQCFDCGQKGPTYVNMTIGSFVCTRCSGVLRGLTPPHRV 66
            |..::||::|:|..||::  :|...||:||||.|:||||||||:||||||.|||.||||.|||||
Human     3 ASAKRKQEEKHLKMLRDM--TGLPHNRKCFDCDQRGPTYVNMTVGSFVCTSCSGSLRGLNPPHRV 65

  Fly    67 KSISMATFTQDEIDFLRSHGNELCAKTWLGLWDPKRAV-----HQQEQRELMMDKYERKRYYLEP 126
            |||||.||||.||:||:.||||:|.:.||||:|.:.:.     ..|:.:|.:.:|||:||:|:.|
Human    66 KSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSSAIPDFRDPQKVKEFLQEKYEKKRWYVPP 130

  Fly   127 --------------------------ASPLKSLANAVNLKSSAPATNHTQNGHQNGYASIHLTP- 164
                                      ..|||||     |..||| |.|...|          ||
Human   131 EQAKVVASVHASISGSSASSTSSTPEVKPLKSL-----LGDSAP-TLHLNKG----------TPS 179

  Fly   165 --PAAQRTSANGLQK------------VANSSSNSSGKTSSSISRPHYNH---QN--NSQNNNHD 210
              |...|:.....:|            :..:.:..|..|::..:..|:|.   ||  |:...|.|
Human   180 QSPVVGRSQGQQQEKKQFDLLSDLGSDIFAAPAPQSTATANFANFAHFNSHAAQNSANADFANFD 244

  Fly   211 AFGLGGGLSSLNSAGSTSTGALSDTSSCASNGFGADCDFVADFGSANIFDATSARSTGSPAVSSV 275
            |||        .|:||::.|           ||                 .|::.|...|..::.
Human   245 AFG--------QSSGSSNFG-----------GF-----------------PTASHSPFQPQTTAF 273

  Fly   276 SSVGSSNGYAKVQ---PIRAAHLQQQQQLQQQLHQQQLLNGNGHQGTENFADFDHAPIYNAVAPP 337
            ..:.||..:.:..   |::|.|                 :|:......|||.||:.|..::....
Human   274 RMLSSSCSFGEFTSAFPLQATH-----------------SGSAASVNANFAHFDNFPKSSSADFG 321

  Fly   338 TFNDWISDWSRRGFHDPFDDCDDSPPGARPPAPAPAPAQVPAVSSPLPTVREEPELAWNFWEDEM 402
            |||
Human   322 TFN-------------------------------------------------------------- 324

  Fly   403 RIEAQEKESQTKQPELGYSFSISTTTPLSPSNPFLPYLVSEEQHRNHPEKPSFSYSLFSSISNSS 467
                   .||:.|       :.|..:.:|.:...|              :.:..|:..:::.|..
Human   325 -------TSQSHQ-------TASAVSKVSTNKAGL--------------QTADKYAALANLDNIF 361

  Fly   468 QEDQADDHEMNVLNANFHDFFTWSAPLQNGHTTSPPKGGNAAMAPSEDRYAALKDLDEQLRELKA 532
            ...|..|.     .:.|..  |..||:  |...|.|...:|    |.|:||||.:||........
Human   362 SAGQGGDQ-----GSGFGT--TGKAPV--GSVVSVPSQSSA----SSDKYAALAELDSVFSSAAT 413

  Fly   533 SESATETPTPTSGNVQATDAFGGALNNNP---------------NPFKGQQQQQLSSHVVNPFQQ 582
            |.:|..:.:..|.||..|.....:....|               |||.......::|. .||||.
Human   414 SSNAYTSTSNASSNVFGTVPVVASAQTQPASSSVPAPFGATPSTNPFVAAAGPSVASS-TNPFQT 477

  Fly   583 QQQQQHQQNLYGQLTL-------------IPNAYGSSSQQQMGHHLLQQQQQQQQSFFNFNNNGF 634
            ..:...... :|..::             :|.::..|.||..   ...|....||:.|:...|||
Human   478 NARGATAAT-FGTASMSMPTGFGTPAPYSLPTSFSGSFQQPA---FPAQAAFPQQTAFSQQPNGF 538

  Fly   635 -AISQGLPNGCGFGSMQPAPVMANNPF---AASGAMNT----NNPFL 673
             |..|..|....||.:..|.| ::|||   |.:|...|    .||||
Human   539 AAFGQTKPVVTPFGQVAAAGV-SSNPFMTGAPTGQFPTGSSSTNPFL 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drongo	NP_001162848.1	ArfGap	15..126	CDD:279720	67/115 (58%)
AGFG1	NP_001128659.1	COG5347	8..319	CDD:227651	122/381 (32%)
AGFG1	NP_001128659.1	ArfGap	14..135	CDD:214518	69/122 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	144	1.000	Domainoid score	I4614
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I4141
Isobase	1	0.950	-	0	Normalized mean entropy	S4766
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002634
OrthoInspector	1	1.000	-	-		oto90702
orthoMCL	1	0.900	-	-		OOG6_104959
Panther	1	1.100	-	-	LDO	PTHR46134
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4960
SonicParanoid	1	1.000	-	-		X3388
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.890