DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drongo and Git1

DIOPT Version :9

Sequence 1:	NP_001162848.1	Gene:	drongo / 33263	FlyBaseID:	FBgn0020304	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_001004144.1	Gene:	Git1 / 216963	MGIID:	1927140	Length:	770	Species:	Mus musculus

Alignment Length:	666	Identity:	120/666 - (18%)
Similarity:	222/666 - (33%)	Gaps:	229/666 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CFDCGQKGPTYVNMTIGSFVCTRCSGVLRGL-----TPPHRVKSISMATFTQDEIDFLRSHG-NE 88
            |.||....|.:.:::.|..||..|..|.|.|     ...|...|....|..| .:..|.|:| |.
Mouse    11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQ-MVHTLASNGANS 74

  Fly    89 LCAKTW-LGLWDP------KRAVHQQEQRELMMDKYERKRYYLEPASPLKSLANAVNLKSSAPAT 146
            :    | ..|.||      :|..:.|::...:..::.|.:|.:
Mouse    75 I----WEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQM---------------------- 113

  Fly   147 NHTQNGHQNGYASIHLTPPAAQRTSANGLQKVANSSSNSSGKTSSSISRPHYNHQNNSQNNNHDA 211
                      .|.:|..|                 ..:..|.|:..:|:
Mouse   114 ----------LAFVHKLP-----------------CRDDDGVTAKDLSK---------------- 135

  Fly   212 FGLGGGLSSLNSAGSTSTGALSDTSSCASNGFGADCDFV-ADFGSANIFDATSARST-------- 267
                    .|:|  |..||.|.......|  .||..:|. .:.|:..:..|..|..|
Mouse   136 --------QLHS--SVRTGNLETCLRLLS--LGAQANFFHPEKGTTPLHVAAKAGQTLQAELLVV 188

  Fly   268 -----GSPAVSSVSSVGSSNGYAKVQPIRAAHLQQQQQLQQQLHQQQLLNGNGHQGTENFADF-- 325
                 |||.|:..:.:    .||:    :|.|    .:|.::|.:.|      ::.|:..|.:
Mouse   189 YGADPGSPDVNGRTPI----DYAR----QAGH----HELAERLVECQ------YELTDRLAFYLC 235

  Fly   326 ----DHAPIYNAVAPPTFNDWISDWSRRGFHDPFDDCDDSPPGARPPAPAPAPAQVPAVSSPLPT 386
                ||...:..:..      ::|.||:.......|..:....|:        .::.|:|:
Mouse   236 GRKPDHKNGHYIIPQ------MADRSRQKCMSQSLDLSELAKAAK--------KKLQALSN---- 282

  Fly   387 VREEPELAWNFWEDEMRIEAQEKESQTKQPELGYSFSISTTTPLSPSNPFLPYLVSEEQHRNHPE 451
             |...|||.:.:::   ::.:|.::.....:     :.||......:.||||.         :||
Mouse   283 -RLFEELAMDVYDE---VDRRENDAVWLATQ-----NHSTLVTERSAVPFLPV---------NPE 329

  Fly   452 KPSFSYSLFSSISNSSQEDQADDHEMNVLNANFHDFFTWSAPL-------QNGHTTSPPKGGNAA 509
                    :|:..|..::..|        ..|..:|.|....:       |.|.:.|.|......
Mouse   330 --------YSATRNQGRQKLA--------RFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLEL 378

  Fly   510 MAPSEDRYAALKDLDEQ--LRELKASESATETPTPTSG--------NVQATDAFGGALNNN---- 560
            .|.|:      .:||:|  ...:.:.|...:.|.|::|        ::.::|...||:...
Mouse   379 SARSQ------SELDDQHDYDSVASDEDTDQEPLPSAGATRNNRARSMDSSDLSDGAVTLQEYLE 437

  Fly   561 ------PNPFKGQQQQQLSSHVVNPFQQQQQQQHQ---QNLYGQLTLIPNAYGSSS--QQQMGHH 614
                  .:..|.||..:::|.:.:..::.|::.|:   :||  ||...|......|  .::..|.
Mouse   438 LKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENL--QLRQPPGPVPPPSLPSERAEHT 500

  Fly   615 LL----QQQQQQQQSF 626
            |:    ...::.:|:|
Mouse   501 LMGPGGSTHRRDRQAF 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drongo	NP_001162848.1	ArfGap	15..126	CDD:279720	27/108 (25%)
Git1	NP_001004144.1	Interaction with gamma-tubulin and localization to the centrosome. /evidence=ECO:0000250\|UniProtKB:Q9Y2X7	1..124		30/166 (18%)
		ArfGap_GIT1	1..111	CDD:350071	26/104 (25%)
		ANK 1	132..161		10/56 (18%)
		Ank_2	137..229	CDD:372319	26/113 (23%)
		ANK repeat	137..165	CDD:293786	10/31 (32%)
		ANK 2	166..195		4/28 (14%)
		ANK repeat	167..197	CDD:293786	6/29 (21%)
		ANK 3	199..228		7/46 (15%)
		Interaction with PCLO. /evidence=ECO:0000250\|UniProtKB:Q9Z272	245..374		30/180 (17%)
		Interaction with PTK2/FAK1. /evidence=ECO:0000250\|UniProtKB:Q9Z272	253..424		39/222 (18%)
		Interaction with ARHGEF7. /evidence=ECO:0000250\|UniProtKB:Q9Z272	254..376		29/167 (17%)
		GIT_SHD	<281..301	CDD:369921	5/27 (19%)
		GIT_SHD	337..365	CDD:369921	4/35 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..425		13/67 (19%)
		Interaction with NCK2 and GRIN3A. /evidence=ECO:0000250\|UniProtKB:Q9Z272	375..596		28/150 (19%)
		Required for localization at synapses. /evidence=ECO:0000250\|UniProtKB:Q9Y2X7	375..596		28/150 (19%)
		GIT_CC	418..482	CDD:374629	13/65 (20%)
		Interaction with MAPK1. /evidence=ECO:0000269\|PubMed:15923189	420..475		9/54 (17%)
		Interaction with IKBKG. /evidence=ECO:0000250\|UniProtKB:Q9Y2X7	429..629		17/90 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..615
		Interaction with PXN and TGFB1I1. /evidence=ECO:0000250\|UniProtKB:Q9Z272	646..770
		GIT1_C	649..763	CDD:371961
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900