DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drongo and Appl2

DIOPT Version :9

Sequence 1:	NP_001162848.1	Gene:	drongo / 33263	FlyBaseID:	FBgn0020304	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_660255.1	Gene:	Appl2 / 216190	MGIID:	2384914	Length:	662	Species:	Mus musculus

Alignment Length:	402	Identity:	69/402 - (17%)
Similarity:	139/402 - (34%)	Gaps:	107/402 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RKKQDDKYLLALRELVASGTGSNRQCFDCGQKGPTYVNMTIGSFVCTRCSGVLRGLTPPHRVKSI 69
            :||:::|   |..|:|.....:.|:           .:::...:.|     .|..|  .:|.::.
Mouse   152 KKKENEK---AKTEIVKEVAAARRK-----------QHLSSLQYYC-----ALNAL--QYRKRAA 195

  Fly    70 SMAT---FTQDEIDFLRSHGNELCAKTWLGLWDPKRAVHQQEQRELMMDKYERKRYYLEPASPLK 131
            .|..   |...:|:|.: .|.|:.:|:..|.....:.:.|..|.||..:..:.:....|    |.
Mouse   196 MMEPLIGFAHGQINFFK-RGAEMFSKSMDGFLSSVKDMVQSIQVELEAEADKMRVSQQE----LL 255

  Fly   132 SLANAVNLKSSAPATNHTQNG--HQNGYASIHLTPPAAQRTSANGLQKVANSSSNSSGKTSSSIS 194
            |::.:|.......||......  .:.||.::.                      |.:|..:::..
Mouse   256 SVSESVYTPDIDVATAQINRNLIQKTGYLNLR----------------------NKTGLVTTTWE 298

  Fly   195 RPHYNHQNNSQNNNHDAFGLGGGLSSLNSAGSTSTGALSDTSSCASNGFGADCD-------FVAD 252
            |.::             |..||.| .....|:.:.|.:.|..:|:.  ...||:       ....
Mouse   299 RLYF-------------FTQGGNL-MCQPRGAVAGGLIQDLDNCSV--MAVDCEDRRYCFQISTP 347

  Fly   253 FGSANIFDATSARSTGSPAVSSVSSVG----------------SSNGYAKVQPIRAAHLQQQQQL 301
            .|...|.....:|......:.:|:::.                :......|.||.:...:|:...
Mouse   348 SGKPGIILQAESRKEYEEWICAVNNISRQIYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSC 412

  Fly   302 -QQQLHQQQLLNGN-GHQGTENFADFDH-----API-YNAVAPPTFNDWISDWSRRGFH-DPFDD 357
             .|.:....:.:.| ..:.|.:..:.:.     .|| ::.|.|.|  ::: |.:|.|.. :||.:
Mouse   413 SSQNIKNSDIEDDNIVPKATASIPETEELIAPGTPIQFDIVLPAT--EFL-DQNRGGRRTNPFGE 474

  Fly   358 CDDSPPGARPPA 369
            .:|   |:.|.|
Mouse   475 TED---GSFPEA 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drongo	NP_001162848.1	ArfGap	15..126	CDD:279720	20/113 (18%)
Appl2	NP_660255.1	BAR_APPL2	20..234	CDD:153316	19/103 (18%)
		BAR-PH_APPL	252..376	CDD:270067	25/165 (15%)
		PH	278..378	CDD:278594	19/137 (14%)
		PH domain	278..376		19/135 (14%)
		PTB_APPL	480..613	CDD:269980	2/4 (50%)
		PTB domain	491..607
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..662
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900