DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drongo and Asap1

DIOPT Version :9

Sequence 1:	NP_001162848.1	Gene:	drongo / 33263	FlyBaseID:	FBgn0020304	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	XP_006520455.1	Gene:	Asap1 / 13196	MGIID:	1342335	Length:	1223	Species:	Mus musculus

Alignment Length:	740	Identity:	121/740 - (16%)
Similarity:	216/740 - (29%)	Gaps:	275/740 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVVRKKQDDKYLLALRELVASGTGS-----------------NRQCFDCGQKGPTYVNMTIGSF 48
            ::|:...:::...:|.|...::|..|                 |..|.|||...||:::..:|..
Mouse   499 ISVLTNSKEEALTMAFRGEQSTGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGIL 563

  Fly    49 VCTRCSGVLRGL-TPPHRVKSISMATFTQDEIDFLRSHGNELCAKTWLGLWD---------PKRA 103
            .|..|||:.|.: ....|::|:.:......|:...::.||    .::..:.:         |..:
Mouse   564 TCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGN----NSFNDIMEANLPSPSPKPTPS 624

  Fly   104 VHQQEQRELMMDKYERKRY----YLEPASPLKSLANAV--------------NLKSSAPATNHTQ 150
            .....::|.:..||...|:    ....::.|..|..|:              .::...|.   .:
Mouse   625 SDMTVRKEYITAKYVDHRFSRKTCASSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPL---LE 686

  Fly   151 NGHQNGYASIHLTPPAAQRTSANGLQKVANSSSNSSGKTSSSISRPHYNHQNNSQNNNHDAFGLG 215
            .|.:.|..::||....|.:||.:.:..:..:..|...:||...:..||
Mouse   687 PGQELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTSVGNTVLHY----------------- 734

  Fly   216 GGLSSLNSAGSTSTGALSDTSSCASNGFGADC-----------DFVADFGSANIFDATSARSTGS 269
                                  |:..| ..:|           |.|...|...:..|...::|..
Mouse   735 ----------------------CSMYG-KPECLKLLLRSKPTVDIVNQNGETALDIAKRLKATQC 776

  Fly   270 PAVSSVSSVGSSNGYAKVQPIRAAHLQQQQQLQQQLHQQQLLNGNGHQGTENFADFDHAPIYNAV 334
            ..:.|.:..|..|.:        .|::.:..|:|.                   :.|.
Mouse   777 EDLLSQAKSGKFNPH--------VHVEYEWNLRQD-------------------EMDE------- 807

  Fly   335 APPTFNDWISDWSRRGFHDPFDDCDDSP-PGARPPAPAP---------APAQ---VPAVSSPLPT 386
                     ||          ||.||.| |..:..:|.|         :|..   :|..|:|
Mouse   808 ---------SD----------DDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTP--- 850

  Fly   387 VREEPELAWNFWEDEMRIEAQEKESQTKQPELGYSFSISTTTPLSPSN--PFLPYLVSEEQHRN- 448
             |::..|::..:.:::                  ..|.||..|.||::  |.||       .||
Mouse   851 -RDKQRLSYGAFTNQI------------------FASTSTDLPTSPTSEAPPLP-------PRNA 889

  Fly   449 --HPEKPSFSYSLFSSISNSSQEDQADDHEMNVLNANFHDFFTWSAPLQNGHTTSPPKGGNAAMA 511
              .|..|..:..|.:..|:.                        |:.|.......||.|....:
Mouse   890 GKGPTGPPSTLPLGTQTSSG------------------------SSTLSKKRPPPPPPGHKRTL- 929

  Fly   512 PSEDRYAALKDLDEQLRELKASESATETPTPTSGNVQATDAFGGALNNNPNPFKGQQQQQLSSHV 576
                                     ::.|:|..         .|..|....|:........||..
Mouse   930 -------------------------SDPPSPLP---------HGPPNKGAIPWGNDVGPLSSSKT 960

  Fly   577 VNPFQQQQQQQHQQNLYGQLTLIPNAYGSSSQQ------QMGHHLLQQQQQQQQSFFNFNNNGFA 635
            .|.|:...||....:  .:..|.|.......|:      :..|||...:.......|..::....
Mouse   961 ANKFEGLSQQASTSS--AKTALGPRVLPKLPQKVALRKTETSHHLSLDRTNIPPETFQKSSQLTE 1023

  Fly   636 ISQGLPNGCGFGSMQPAPV-MANNP 659
            :.|..|    .|.:.|.|| :|..|
Mouse  1024 LPQKPP----LGELPPKPVELAPKP 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drongo	NP_001162848.1	ArfGap	15..126	CDD:279720	27/141 (19%)
Asap1	XP_006520455.1	BAR_ASAP1	138..344	CDD:153325
		PH_ASAP	407..513	CDD:270071	1/13 (8%)
		ArfGap_ASAP1	528..649	CDD:350073	23/124 (19%)
		ANK repeat	692..725	CDD:293786	7/32 (22%)
		Ank_2	696..>768	CDD:372319	16/111 (14%)
		ANK repeat	727..758	CDD:293786	6/70 (9%)
		Atrophin-1	845..>1109	CDD:367360	51/294 (17%)
		SH3_ASAP1	1165..1221	CDD:212898
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900