DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drongo and AGAP4

DIOPT Version :9

Sequence 1:	NP_001162848.1	Gene:	drongo / 33263	FlyBaseID:	FBgn0020304	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_001263272.2	Gene:	AGAP4 / 119016	HGNCID:	23459	Length:	686	Species:	Homo sapiens

Alignment Length:	205	Identity:	50/205 - (24%)
Similarity:	81/205 - (39%)	Gaps:	36/205 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NRQCFDCGQKGPTYVNMTIGSFVCTRCSGVLRGL-TPPHRVKSISMATFTQDEIDFLRSHGNELC 90
            |..|.||..:.|.:.::.:|..:|..|||:.|.| |...||:|:.:..:..:....:.|.||:|.
Human   476 NAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 540

  Fly    91 AKTW----LGLWDPKRAVHQQEQRELMMDKYERKRYYLEP--------------ASPLKSLANAV 137
            ...|    .|...|.....::|:...:..|||.| .:|.|              |:..:.|..|:
Human   541 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEK-LFLAPLPCTELSLGQQLLRATADEDLQTAI 604

  Fly   138 NL--KSSAPATNHTQNGHQNGYASIHL-----TPPAAQRTSANGLQKVANSSSNSSGKTSSSISR 195
            .|  ..|....|.| .|..:|..::||     ....||.....|:..:|..:..::..|
Human   605 LLLAHGSREEVNET-CGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALT------ 662

  Fly   196 PHYNHQNNSQ 205
              |..|.:||
Human   663 --YARQASSQ 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drongo	NP_001162848.1	ArfGap	15..126	CDD:279720	29/103 (28%)
AGAP4	NP_001263272.2	PH_AGAP	280..447	CDD:241281
		PH	283..442	CDD:278594
		ArfGap	466..580	CDD:279720	29/104 (28%)
		Ank_2	591..681	CDD:289560	20/89 (22%)
		ANK repeat	591..621	CDD:293786	7/30 (23%)
		ANK	<594..677	CDD:238125	20/86 (23%)
		ANK repeat	623..654	CDD:293786	7/30 (23%)
		ANK repeat	656..681	CDD:293786	5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900