DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drongo and ACAP3

DIOPT Version :9

Sequence 1:	NP_001162848.1	Gene:	drongo / 33263	FlyBaseID:	FBgn0020304	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	XP_011538908.1	Gene:	ACAP3 / 116983	HGNCID:	16754	Length:	844	Species:	Homo sapiens

Alignment Length:	335	Identity:	77/335 - (22%)
Similarity:	130/335 - (38%)	Gaps:	65/335 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NRQCFDCGQKGPTYVNMTIGSFVCTRCSGVLRGL-TPPHRVKSISMATFTQDEIDFLRSHGNELC 90
            |.||.||||..|.:.::.:|..:|..|||:.|.| ....:|:|:::.::..:.:..:...||...
Human   425 NSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAV 489

  Fly    91 AKTW------LGLWDPKRAVHQQEQRELMMDKYERKRYYLEPASPLKSLANAVNLKSSAPATNHT 149
            .:.:      .|...|..:..:|::...:.|||..|::..:  :|:            |||....
Human   490 NQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRK--APM------------APALEAP 540

  Fly   150 QNGHQNGYASIHLTP--PAAQRTSANGLQKV--ANSSSNSSGKTSSSISRPHY--NHQNNSQNNN 208
            :..........|.:|  |.|:|...  |:.|  ..::.:|.|.......|...  ..:.:|..:.
Human   541 RRWRVQKCLRPHSSPRAPTARRKVR--LEPVLPCVAALSSVGTLDRKFRRDSLFCPDELDSLFSY 603

  Fly   209 HDAFGLGGGLSSLNSAGSTSTGALSDTSSCASNGFGADCDFVADFGSANIFDATSARSTGSPAVS 273
            .||...|.|..||:|  .:..|..||.||          |.:| |||.::.|:.:.........|
Human   604 FDAGAAGAGPRSLSS--DSGLGGSSDGSS----------DVLA-FGSGSVVDSVTEEEGAESEES 655

  Fly   274 SVSSVGSSN----GYAKVQPI-------RAAHLQQQQQLQQQLHQQQLLNGNGHQGTENFADFD- 326
            |..:.|.:.    |.|.|:.:       |||..:....|...|         .|....|:||.:
Human   656 SGEADGDTEAEAWGLADVRELHPGLLAHRAARARDLPALAAAL---------AHGAEVNWADAED 711

  Fly   327 --HAPIYNAV 334
              ..|:..||
Human   712 EGKTPLVQAV 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drongo	NP_001162848.1	ArfGap	15..126	CDD:279720	26/105 (25%)
ACAP3	XP_011538908.1	BAR	16..225	CDD:299863
		PH	279..373	CDD:278594
		PH_ACAP	281..377	CDD:270070
		ArfGap	413..531	CDD:279720	26/107 (24%)
		ANK	711..>798	CDD:238125	3/11 (27%)
		ANK repeat	712..743	CDD:293786	3/10 (30%)
		Ank_4	715..766	CDD:290365	3/7 (43%)
		ANK repeat	745..776	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900