DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dock and NCK2

DIOPT Version :9

Sequence 1:	NP_001259845.1	Gene:	dock / 33262	FlyBaseID:	FBgn0010583	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001004720.1	Gene:	NCK2 / 8440	HGNCID:	7665	Length:	380	Species:	Homo sapiens

Alignment Length:	416	Identity:	177/416 - (42%)
Similarity:	246/416 - (59%)	Gaps:	71/416 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 VVAKYDYAAQGAQELDLRKNERYLLLDDSKHWWRVQNSRNQSGYVPSNYVKKEKPSLFDSIKKKV 219
            |:||:||.||..||||::||||..||||||.||||:|:.|::||||||||::         |..:
Human     7 VIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVER---------KNSL 62

  Fly   220 KKGSGSKTLPNCSPSRQVESPTMSRRLPPD-------PAEAIGT---------AVVKYNYQAQQP 268
            ||||..|.|.:.....:....|.:|...|.       ||...|.         |.||:.|.|::.
Human    63 KKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAERE 127

  Fly   269 DELSLTKGTRILILEKSNDGWWRGQSGNSVGWFPSNYTTEDCD------------NDGEIHTYAM 321
            |||||.||:|:.::||.:||||||.....:|||||||..|:.|            ..|...:...
Human   128 DELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKGASLSNGQ 192

  Fly   322 AENVLDIVVALYSFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARNNQGQVGLVPRNYLQELND 386
            ...||.:|..||.|:|..::||:||||:.:|::::|.:||:|:|.:|.:|||||||:||:..|:|
Human   193 GSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSD 257

  Fly   387 YLATPYRNASASAGNGNGGGSNGGAGGGGGNDSMERRNEGNKPAAQSSGQPIERPNLAGKSWYYG 451
            ..|....:|...:..|                            ..|||:      .||:.||||
Human   258 GPALHPAHAPQISYTG----------------------------PSSSGR------FAGREWYYG 288

  Fly   452 AITRSQCDTVLNGHGHDGDFLIRDSETNMGDYSVSLKAPGRNKHFRVHVEQNMYCIGQRKFHSLD 516
            .:||.|.:..||..|.:|||||||||::..|:||||||.|:||||:|.:..|:||||||:||::|
Human   289 NVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIGQRRFHTMD 353

  Fly   517 QLVDHYQRAPIYTNKQGEKLYLVRSL 542
            :||:||::|||:|::.||||||||:|
Human   354 ELVEHYKKAPIFTSEHGEKLYLVRAL 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_001259845.1	SH3_Nck_1	154..204	CDD:212699	33/48 (69%)
		SH3_Nck_2	256..308	CDD:212700	28/60 (47%)
		SH3_Nck_3	328..383	CDD:212701	27/54 (50%)
		SH2_Nck_family	446..538	CDD:198196	54/91 (59%)
NCK2	NP_001004720.1	SH3_Nck2_1	2..59	CDD:212832	35/60 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..102		4/22 (18%)
		SH3_Nck2_2	114..168	CDD:212835	28/53 (53%)
		SH3_Nck2_3	198..256	CDD:212836	27/57 (47%)
		SH2_Nck2	283..380	CDD:198272	59/97 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148267
Domainoid	1	1.000	110	1.000	Domainoid score	I6300
eggNOG	1	0.900	-	-		E1_KOG4226
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2370
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46567
OrthoDB	1	1.010	-	-		D1097449at2759
OrthoFinder	1	1.000	-	-		FOG0002240
OrthoInspector	1	1.000	-	-		otm40407
orthoMCL	1	0.900	-	-		OOG6_106243
Panther	1	1.100	-	-	O	PTHR19969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4150
SonicParanoid	1	1.000	-	-		X1672
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800