DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dock and SLA2

DIOPT Version :9

Sequence 1:	NP_001259845.1	Gene:	dock / 33262	FlyBaseID:	FBgn0010583	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_016883587.1	Gene:	SLA2 / 84174	HGNCID:	17329	Length:	288	Species:	Homo sapiens

Alignment Length:	213	Identity:	54/213 - (25%)
Similarity:	76/213 - (35%)	Gaps:	78/213 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 AENVLDIVVALYSFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARNNQGQVGLVPRNYLQELND 386
            ||......|||.||.:....|||...|:.|.||   :.|.||:              ..|.|:
Human    30 AERSKATAVALGSFPAGGPAELSLRLGEPLTIV---SEDGDWW--------------TVLSEV-- 75

  Fly   387 YLATPYRNASASAGNGNGGGSNGGAGGGGGNDSMERRNEGNKPAAQSSGQPIERPNL----AGKS 447
                                                           ||:....|::    ....
Human    76 -----------------------------------------------SGREYNIPSVHVAKVSHG 93

  Fly   448 WYYGAITRSQCDTVLNGHGHDGD-FLIRDSETNMGDYSVS--LKAPG---RNKHFRVHVEQN--M 504
            |.|..::|.:.:.:|...|:.|. ||||:|:|..|.||:|  |..|.   |.:|:|:|...|  :
Human    94 WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWL 158

  Fly   505 YCIGQRKFHSLDQLVDHY 522
            |...:..|.||..|||||
Human   159 YISPRLTFPSLQALVDHY 176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_001259845.1	SH3_Nck_1	154..204	CDD:212699
		SH3_Nck_2	256..308	CDD:212700
		SH3_Nck_3	328..383	CDD:212701	16/54 (30%)
		SH2_Nck_family	446..538	CDD:198196	32/85 (38%)
SLA2	XP_016883587.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148272
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840