DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dock and sla1a

DIOPT Version :9

Sequence 1:	NP_001259845.1	Gene:	dock / 33262	FlyBaseID:	FBgn0010583	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001030161.1	Gene:	sla1a / 571922	ZFINID:	ZDB-GENE-050904-3	Length:	271	Species:	Danio rerio

Alignment Length:	201	Identity:	43/201 - (21%)
Similarity:	78/201 - (38%)	Gaps:	70/201 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 DIVVALYSFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARNNQ-GQVGLVPRNYLQELNDYLAT 390
            |.:|.|..:...:..|..|:.||||:.:   :.|..|:|.|:.| |....:|.|::.::
Zfish    25 DTLVVLADYPCRDISEPVFKMGDRLKGL---SEDGCWWKVRSLQTGTENYIPCNHVSKV------ 80

  Fly   391 PYRNASASAGNGNGGGSNGGAGGGGGNDSMERRNEGNKPAAQSSGQPIERPNLAGKSWYYGAITR 455
             |.                                                     .|.:..::|
Zfish    81 -YH-----------------------------------------------------GWLFEGVSR 91

  Fly   456 SQCDTVLNGHGHD-GDFLIRDSETNMGDYSVSLKAPGRN-KHFRV-HVEQNMYCIGQR-KFHSLD 516
            .:.:.:|:..|:. |.||||:|....|.||:|::  .|: ||::: .:..:.|.|..| .|..|:
Zfish    92 QKAEELLSLPGNSAGSFLIRESPRERGLYSLSVR--HRSVKHYKIFRLTNSWYYISPRLTFQCLE 154

  Fly   517 QLVDHY 522
            .:|:||
Zfish   155 DMVNHY 160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_001259845.1	SH3_Nck_1	154..204	CDD:212699
		SH3_Nck_2	256..308	CDD:212700
		SH3_Nck_3	328..383	CDD:212701	16/55 (29%)
		SH2_Nck_family	446..538	CDD:198196	25/81 (31%)
sla1a	NP_001030161.1	SH3_SLAP	26..80	CDD:212943	16/56 (29%)
sla1a	NP_001030161.1	SH2_SLAP	73..170	CDD:198207	28/150 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582185
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930