DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dock and nck1a

DIOPT Version :9

Sequence 1:	NP_001259845.1	Gene:	dock / 33262	FlyBaseID:	FBgn0010583	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_693006.3	Gene:	nck1a / 564584	ZFINID:	ZDB-GENE-070912-547	Length:	310	Species:	Danio rerio

Alignment Length:	352	Identity:	137/352 - (38%)
Similarity:	197/352 - (55%)	Gaps:	60/352 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 EKPSLFDSIKK--KVKKGSGSKTLPNCSPSRQVESPTMSRRLPPDPAEAIGTAVVKYNYQAQQPD 269
            |..:||....:  |||:....:.||:.:...:.:.......||         |:||:||.|::.|
Zfish     2 EMANLFKHFFRIGKVKQKGCVRDLPSSAEKYEGDERLYDLNLP---------ALVKFNYTAERED 57

  Fly   270 ELSLTKGTRILILEKSNDGWWRGQSGNSVGWFPSNYTTEDCD--------NDGEIHTYAMAEN-- 324
            ||||.||||::::||.:||||||......|||||||.|||.|        |..::.:.....|
Zfish    58 ELSLVKGTRVIVMEKCSDGWWRGSYNGLSGWFPSNYVTEDVDGTMRVDSVNPDKLASVGHNNNSS 122

  Fly   325 -VLDIVVALYSFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARNNQGQVGLVPRNY---LQELN 385
             ||..|.|||.|:|.|.:||:|.|.:.::::::|.:||:|:|.|...|||||||:||   :|:.:
Zfish   123 QVLQTVQALYHFSSGNVEELNFNKYELMDVLEKPENDPEWWKCRKENGQVGLVPKNYVTVVQKTH 187

  Fly   386 DYLATPYRNASASAGNGNGGGSNGGAGGGGGNDSMERRNEGNKPAAQSSGQPIERPNLAGKSWYY 450
            ..|                       |..|.:.|    |...||:...        ...||.|||
Zfish   188 KEL-----------------------GISGPHPS----NYDIKPSMDG--------KFGGKQWYY 217

  Fly   451 GAITRSQCDTVLNGHGHDGDFLIRDSETNMGDYSVSLKAPGRNKHFRVHVEQNMYCIGQRKFHSL 515
            |.:||.|.:.|||..|.||||||||||:...|:|:||||..:||||:|.:....:|||||||.::
Zfish   218 GKLTRHQAEMVLNQRGVDGDFLIRDSESMPNDFSISLKALYKNKHFKVLLNDGFFCIGQRKFSTM 282

  Fly   516 DQLVDHYQRAPIYTNKQGEKLYLVRSL 542
            :.||:||::|||:|::.|:||||::.|
Zfish   283 EDLVEHYKKAPIFTSEHGDKLYLIKPL 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_001259845.1	SH3_Nck_1	154..204	CDD:212699
		SH3_Nck_2	256..308	CDD:212700	30/51 (59%)
		SH3_Nck_3	328..383	CDD:212701	26/57 (46%)
		SH2_Nck_family	446..538	CDD:198196	51/91 (56%)
nck1a	XP_693006.3	SH3_Nck1_2	42..96	CDD:212834	32/62 (52%)
		SH3	126..182	CDD:302595	26/55 (47%)
		SH2	213..309	CDD:301589	53/95 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582190
Domainoid	1	1.000	107	1.000	Domainoid score	I6441
eggNOG	1	0.900	-	-		E1_KOG4226
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2346
OMA	1	1.010	-	-		QHG46567
OrthoDB	1	1.010	-	-		D459027at33208
OrthoFinder	1	1.000	-	-		FOG0002240
OrthoInspector	1	1.000	-	-		otm25815
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19969
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1672
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910