DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dock and Sla2

DIOPT Version :9

Sequence 1:	NP_001259845.1	Gene:	dock / 33262	FlyBaseID:	FBgn0010583	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001165589.1	Gene:	Sla2 / 499931	RGDID:	1562071	Length:	263	Species:	Rattus norvegicus

Alignment Length:	262	Identity:	57/262 - (21%)
Similarity:	93/262 - (35%)	Gaps:	89/262 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 RGQSGNSVGWFPSNYTTEDCDNDGEIHTYAMAENVLDIVVALYSFTSNNDQELSFEKGDRLEIVD 355
            ||::.:     ||  ::......|:......||......|||.||.:.....||...|:.|.|:
  Rat     8 RGKNSS-----PS--SSSSFSGPGQEPVSIQAERQKVSAVALGSFPAGEQARLSLRVGEPLTII- 64

  Fly   356 RPASDPDWYKARNN-QGQVGLVPRNYLQELNDYLATPYRNASASAGNGNGGGSNGGAGGGGGNDS 419
              :.|.||:..::. .|:...:|..|:.::                      |:|
  Rat    65 --SEDGDWWTVQSEVSGREYHIPSVYVAKV----------------------SHG---------- 95

  Fly   420 MERRNEGNKPAAQSSGQPIERPNLAGKSWYYGAITRSQCDTVLNGHGHDGD-FLIRDSETNMGDY 483
                                        |.|..::|.:.:.:|...|:.|. ||||:|:|..|.|
  Rat    96 ----------------------------WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCY 132

  Fly   484 SVSLKAP-----GRNKHFRVHVEQN--MYCIGQRKFHSLDQLVDHYQ----------RAPIYTNK 531
            |:|::..     .|.:|:|:....|  :|...:..|.||..||:||.          |.|....|
  Rat   133 SLSIRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCALREPCVLQK 197

  Fly   532 QG 533
            .|
  Rat   198 LG 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_001259845.1	SH3_Nck_1	154..204	CDD:212699
		SH3_Nck_2	256..308	CDD:212700	4/16 (25%)
		SH3_Nck_3	328..383	CDD:212701	16/55 (29%)
		SH2_Nck_family	446..538	CDD:198196	32/106 (30%)
Sla2	NP_001165589.1	SH3	39..92	CDD:302595	16/55 (29%)
Sla2	NP_001165589.1	SH2_SLAP	85..187	CDD:198207	32/161 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342149
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930