Protein Alignment dock and Csk

DIOPT Version :10

• Sequence 1: NP_722657.1
• Gene: dock / 33262
• FlyBaseID: FBgn0010583
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 560
• Identity: 109/560 - (19%)
• Similarity: 165/560 - (29%)
• Gaps: 180/560 - (32%)

  Fly    15 SSASSQQYPQQQQH--PPQLPQHQNLNLNQNQN--------------------LNQNQIYQYRPQ 57
            |:|....:.|...|  ||..|...|.......|                    |:|.|:.|.:|.
  Fly   366 STAGDPWFLQTTGHQMPPTAPLRHNKRPAPQPNAVLGAGSSGTAPGSAVGAVLLHQQQLSQSQPH 430

  Fly    58 VPVPVPGSPAHHQRHSSLSQQQQLHHHRTLST----ASSCSAQHKSVTFGQPALDCGGNGSGSAN 118
            : || |..|.||            ||||..:.    |.:.:|.|.|           .:...|.|
  Fly   431 I-VP-PSIPPHH------------HHHRENNVHPIQAGAAAALHLS-----------SHALNSHN 470

  Fly   119 GSGSGNSSSGSAAGNAGTQSMAGNMKHGKSQDDVCYVVAKYDYAAQGAQELDLRKNERYLLLDDS 183
            ...|.::.|..:......|....|.:..:.|....:.:.
  Fly   471 LISSASNHSPKSPSQTQQQQQTTNQQQQQQQQQASHSIL-------------------------- 509

  Fly   184 KHWWRVQNSRNQSGYVPSNYVKKEKPSLFDSIKKKVKKGSGSKTLPNCSPSRQVESPTMSRRLPP 248
                        |.:.|                                      :||::...|.
  Fly   510 ------------STFAP--------------------------------------APTVAAVQPA 524

  Fly   249 DPAEAIGT-AVVKYNYQAQQPDELSLTKGTRILILEKSNDGWWRGQSGNSVGWFPSNYTTEDCDN 312
            ......|| |.|....|.||...|.|        |.....|        ..|...|:........
  Fly   525 GSQSVAGTAAAVAAVAQQQQQQHLQL--------LANCPPG--------GAGLMSSSLNAAQMGM 573

  Fly   313 DGEIHTYAMAENVLDIVVALYSFTSNNDQELSFEKGDRLEIVDRP--ASDPDWYKARNNQGQVGL 375
            .|       ||..|.......|.:.:....|       |....:|  ||.|......:..|..|:
  Fly   574 HG-------AERALPPKSLALSGSQHGSNML-------LHTAPQPPQASQPAAVVGVSGSGSAGM 624

  Fly   376 VPRNYLQELNDYLATPYRNASASAGNGNGGGSNGGAGGGGGNDSMERRNEGNKPAAQSSGQPIER 440
            ....:..::|          ..:||:|....|   |...|...:|...:......|...|:....
  Fly   625 STSLHSFDIN----------GVTAGSGVNASS---AWSSGSTTAMNHASLSPTALAPQQGRSRCE 676

  Fly   441 PNLAGKSWYYGAITRSQCDTVLNGHGHDGDFLIRDSETNMGDYSVSLKAPGRNKHFRVHVEQNMY 505
            ..|....|::|:|||.:.:.:|... .||.||:|:|....|||::.:....:.:|:||...:|..
  Fly   677 VKLNAMPWFHGSITRDEAEHLLQPR-EDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKL 740

  Fly   506 CIGQRK-FHSLDQLVDHYQRAPIYTNKQGEKLYLVRSLPK 544
            .|...: |.:|.|||.||:     .:..|....|::.|||
  Fly   741 TIDDEEYFENLGQLVAHYE-----ADADGLCTQLIKCLPK 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_722657.1	SH3_Nck_1	154..204	CDD:212699	2/49 (4%)
		SH3_Nck_2	256..308	CDD:212700	12/52 (23%)
		SH3_Nck_3	328..383	CDD:212701	9/56 (16%)
		SH2_Nck_family	446..538	CDD:198196	28/92 (30%)
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	32/102 (31%)
		PTKc_Csk_like	793..1047	CDD:270635