DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dock and nck2a

DIOPT Version :9

Sequence 1:	NP_001259845.1	Gene:	dock / 33262	FlyBaseID:	FBgn0010583	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_957291.1	Gene:	nck2a / 393972	ZFINID:	ZDB-GENE-040426-686	Length:	403	Species:	Danio rerio

Alignment Length:	447	Identity:	176/447 - (39%)
Similarity:	256/447 - (57%)	Gaps:	110/447 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 VVAKYDYAAQGAQELDLRKNERYLLLDDSKHWWRVQNSRNQSGYVPSNYVKK----EKPSLFDSI 215
            |:||:||.||..||||:|||||..||||||.||||:|:.|::||||||||::    :|.||..::
Zfish     7 VIAKWDYTAQQDQELDIRKNERLWLLDDSKTWWRVRNASNRTGYVPSNYVERKNSLKKTSLVKNL 71

  Fly   216 KK-----KVKKGSGSKTLPNCSPSRQVESPT---------------MSRRLPPDPAEAIGTAVVK 260
            |.     |.|:.:.::. |:.:||.:.|.|:               ....:|         |:||
Zfish    72 KDTLGLGKTKRKTSARD-PSPTPSTEAEYPSNGSAGGGGGGGAERIYDLNIP---------ALVK 126

  Fly   261 YNYQAQQPDELSLTKGTRILILEKSNDGWWRGQSGNSVGWFPSNYTTED---CDNDGEI------ 316
            ::|.|::.|||:|.||.|::::||.:||||||.....||||||||..|:   .||||..
Zfish   127 FSYAAERDDELNLVKGERVVVMEKCSDGWWRGSHAGRVGWFPSNYVQEEVGYTDNDGVFGDTVGG 191

  Fly   317 -------HTYAMA--------ENVLDIVVALYSFTSNNDQELSFEKGDRLEIVDRPASDPDWYKA 366
                   ...|||        .:||.:|..||.|:|..::||:||||:.:|::::|.:||:|::.
Zfish   192 FRSLKVGQGAAMANGRPGGSGSSVLHVVQTLYPFSSVTEEELNFEKGETMEVLEKPENDPEWWRC 256

  Fly   367 RNNQGQVGLVPRNYLQELNDYLATPYRNASASAGNGNGGGSNGGAGGGGGNDSMERRNEGNKPAA 431
            :|::|.|||||:||:..|:|                                         .|.|
Zfish   257 KNSRGIVGLVPKNYVVVLDD-----------------------------------------GPVA 280

  Fly   432 QSSGQPIERPNL-----------AGKSWYYGAITRSQCDTVLNGHGHDGDFLIRDSETNMGDYSV 485
            :|.|.....|::           |||.||||.:||...:..||..|.:|||||||||::..|:|:
Zfish   281 KSLGSSHGSPHISHTVPSRVGKFAGKGWYYGNVTRHHAECALNERGVEGDFLIRDSESSPSDFSI 345

  Fly   486 SLKAPGRNKHFRVHVEQNMYCIGQRKFHSLDQLVDHYQRAPIYTNKQGEKLYLVRSL 542
            ||||.|:||||:|..:...||||||:|.|:|:||:||::|||:|::||:|||||::|
Zfish   346 SLKAVGKNKHFKVQHQDGAYCIGQRRFSSMDELVEHYKKAPIFTSEQGDKLYLVKAL 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_001259845.1	SH3_Nck_1	154..204	CDD:212699	34/48 (71%)
		SH3_Nck_2	256..308	CDD:212700	28/51 (55%)
		SH3_Nck_3	328..383	CDD:212701	25/54 (46%)
		SH2_Nck_family	446..538	CDD:198196	52/91 (57%)
nck2a	NP_957291.1	SH3_Nck2_1	2..59	CDD:212832	36/51 (71%)
		SH3_Nck_2	122..174	CDD:212700	29/60 (48%)
		SH3_Nck2_3	217..275	CDD:212836	25/57 (44%)
		SH2_Nck2	306..403	CDD:198272	56/97 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582183
Domainoid	1	1.000	107	1.000	Domainoid score	I6441
eggNOG	1	0.900	-	-		E1_KOG4226
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2346
OMA	1	1.010	-	-		QHG46567
OrthoDB	1	1.010	-	-		D1097449at2759
OrthoFinder	1	1.000	-	-		FOG0002240
OrthoInspector	1	1.000	-	-		otm25815
orthoMCL	1	0.900	-	-		OOG6_106243
Panther	1	1.100	-	-	O	PTHR19969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4150
SonicParanoid	1	1.000	-	-		X1672
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800