DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dock and grap2b

DIOPT Version :9

Sequence 1:	NP_001259845.1	Gene:	dock / 33262	FlyBaseID:	FBgn0010583	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_956972.1	Gene:	grap2b / 393651	ZFINID:	ZDB-GENE-040426-1485	Length:	249	Species:	Danio rerio

Alignment Length:	228	Identity:	53/228 - (23%)
Similarity:	86/228 - (37%)	Gaps:	86/228 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 YSFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARNNQGQVGLVPRNYLQELNDYLATPYRNASA 397
            |.|::....||||.|||.::|:   .::.||::|..| |..|.||||       |:.|.:
Zfish     7 YDFSATAGDELSFRKGDVIKIL---GTNDDWFRAEIN-GMEGFVPRN-------YIVTTF----- 55

  Fly   398 SAGNGNGGGSNGGAGGGGGNDSMERRNEGNKPAAQSSGQPIERPNLAGKSWYYGAITRS------ 456
                                                            .|||....:|.
Zfish    56 ------------------------------------------------PSWYKENTSRQSAQDEL 72

  Fly   457 QCDTVLNGHGHDGDFLIRDSETNMGDYSVSLKAPGRNKHFRV-HVEQNMYCIGQRKFHSLDQLVD 520
            .|..:       |.|:||.|:::.||:|:|::.....:||:| ...|..|.:....|.||::|||
Zfish    73 MCQPI-------GAFIIRGSQSSPGDFSISVRHENDVQHFKVMRDRQGRYYLWSEMFTSLNKLVD 130

  Fly   521 HY--------QRAPIYTNKQGEKLYLVRSLPKA 545
            :|        .|..:.|:::....:|.|...:|
Zfish   131 YYTHNSISKQSRVFLLTDQRSSSDFLHRKPTEA 163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_001259845.1	SH3_Nck_1	154..204	CDD:212699
		SH3_Nck_2	256..308	CDD:212700
		SH3_Nck_3	328..383	CDD:212701	20/49 (41%)
		SH2_Nck_family	446..538	CDD:198196	28/106 (26%)
grap2b	NP_956972.1	SH3	2..51	CDD:302595	20/54 (37%)
		SH2_Grb2_like	54..147	CDD:199828	27/152 (18%)
		SH3	197..248	CDD:302595
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582194
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840