DRSC/TRiP Functional Genomics Resources

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Protein Alignment dock and HCK

DIOPT Version :10

Sequence 1:NP_722657.1 Gene:dock / 33262 FlyBaseID:FBgn0010583 Length:548 Species:Drosophila melanogaster
Sequence 2:NP_002101.2 Gene:HCK / 3055 HGNCID:4840 Length:526 Species:Homo sapiens


Alignment Length:331 Identity:74/331 - (22%)
Similarity:121/331 - (36%) Gaps:130/331 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   206 KEKPSLFDSIKKKVKKGSG---SKTLPNCSPSRQVESPTMSRRLPPDPAEAIGTAVVKYNYQAQQ 267
            :|:......:|.|..:..|   |||..:.||...|        ..|||...|......:|     
Human    16 EERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPV--------YVPDPTSTIKPGPNSHN----- 67

  Fly   268 PDELSLTKGTRILILEKSNDGWWRGQSGNSVGWFPSNYTTEDCDNDGEIHTYAMAENVLDIVVAL 332
                |.|.|.|              ::|           :||.                 |||||
Human    68 ----SNTPGIR--------------EAG-----------SEDI-----------------IVVAL 86

  Fly   333 YSFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARN-NQGQVGLVPRNYLQELNDYLATPYRNAS 396
            |.:.:.:.::|||:|||::.:::...   :|:|||: ...:.|.:|.||:..:            
Human    87 YDYEAIHHEDLSFQKGDQMVVLEESG---EWWKARSLATRKEGYIPSNYVARV------------ 136

  Fly   397 ASAGNGNGGGSNGGAGGGGGNDSMERRNEGNKPAAQSSGQPIERPNLAGKSWYYGAITRSQCDTV 461
                                 ||:|.                       :.|::..|:|...:..
Human   137 ---------------------DSLET-----------------------EEWFFKGISRKDAERQ 157

  Fly   462 LNGHGHD-GDFLIRDSETNMGDYSVSLK--APGRN---KHFRVHVEQN--MYCIGQRKFHSLDQL 518
            |...|:. |.|:||||||..|.||:|::  .|.:.   ||:::....|  .|...:..|.:|.:|
Human   158 LLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQEL 222

  Fly   519 VDHYQR 524
            ||||::
Human   223 VDHYKK 228

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dockNP_722657.1 SH3_Nck_1 154..204 CDD:212699
SH3_Nck_2 256..308 CDD:212700 6/51 (12%)
SH3_Nck_3 328..383 CDD:212701 20/55 (36%)
SH2_Nck_family 446..538 CDD:198196 29/87 (33%)
HCKNP_002101.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20 1/3 (33%)
SH3 82..137 CDD:473055 20/90 (22%)
SH2_Src_HCK 140..243 CDD:198226 30/112 (27%)
Protein Kinases, catalytic domain 254..524 CDD:473864
Blue background indicates that the domain is not in the aligned region.

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