Protein Alignment dock and SH3KBP1

DIOPT Version :10

• Sequence 1: NP_722657.1
• Gene: dock / 33262
• FlyBaseID: FBgn0010583
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_001397685.1
• Gene: SH3KBP1 / 30011
• HGNCID: 13867
• Length: 709
• Species: Homo sapiens
• Alignment Length: 267
• Identity: 68/267 - (25%)
• Similarity: 106/267 - (39%)
• Gaps: 59/267 - (22%)

  Fly   257 AVVKYNYQAQQPDELSLTKGTRILILEKSNDGWWRGQSGNSVGWFPSNYTTE---DCDND----- 313
            |:|:::||||..|||:::.|..|..:.|.:.|||.||.....|.||.|:..|   :...|
Human     4 AIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNK 68

  Fly   314 ---GEIHTYAMAENVLDIVVAL----------------YSFTSNNDQELSFEKGDRLEIVDRPAS 359
               ..:|......::|.....|                :|:...||.||..:.||.:|:|..  .
Human    69 APEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGE--V 131

  Fly   360 DPDWYKARNNQGQVGLVPRNYLQELNDYLATPYRNASASAGNGNGGGSNGGAGGGGGNDSMERRN 424
            :..|::...| |:.|:.|.|:::||:                    |.:...|........:.|.
Human   132 EEGWWEGVLN-GKTGMFPSNFIKELS--------------------GESDELGISQDEQLSKSRP 175

  Fly   425 EGNKPAAQSSGQPIERPNLAGKSWYYGAITRSQCDTVLNGHGHDGDFLIRD---SETNMGDYSVS 486
            ||..||   |..|.......||:.:.|.|..........||..  .:.:|:   ||::.|| |.|
Human   176 EGLPPA---SLLPFPAHGAKGKTTFEGTILYRAAPGKTEGHRR--YYSLRETTGSESDGGD-SSS 234

  Fly   487 LKAPGRN 493
            .|:.|.|
Human   235 TKSEGAN 241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_722657.1	SH3_Nck_1	154..204	CDD:212699
		SH3_Nck_2	256..308	CDD:212700	21/50 (42%)
		SH3_Nck_3	328..383	CDD:212701	16/70 (23%)
		SH2_Nck_family	446..538	CDD:198196	15/51 (29%)
SH3KBP1	NP_001397685.1	SH3_CIN85_1	3..55	CDD:212985	21/50 (42%)
		SH3_CIN85_2	102..154	CDD:212988	15/54 (28%)
		SH3_CIN85_3	315..370	CDD:212990