Protein Alignment dock and FYN

DIOPT Version :10

• Sequence 1: NP_722657.1
• Gene: dock / 33262
• FlyBaseID: FBgn0010583
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_002028.1
• Gene: FYN / 2534
• HGNCID: 4037
• Length: 537
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 75/321 - (23%)
• Similarity: 124/321 - (38%)
• Gaps: 110/321 - (34%)

  Fly   217 KKVKKGSGSKTLPNCSPSRQVESPTMSRRLPPDPAEAIG-TAVVKY-NYQAQQPDELSLTKGTRI 279
            |..::..||  |...|..|....||      |....:.| |::..| |:.|.....|::..|
Human    13 KLTEERDGS--LNQSSGYRYGTDPT------PQHYPSFGVTSIPNYNNFHAAGGQGLTVFGG--- 66

  Fly   280 LILEKSNDGWWRGQSGNSVGWFPSNYTTEDCDNDGEIHTYAMAENVLDIVVALYSFTSNNDQELS 344
             :...|:.|..|.:.|..|..|                            ||||.:.:..:.:||
Human    67 -VNSSSHTGTLRTRGGTGVTLF----------------------------VALYDYEARTEDDLS 102

  Fly   345 FEKGDRLEIVDRPASDPDWYKARN-NQGQVGLVPRNYLQELNDYLATPYRNASASAGNGNGGGSN 408
            |.||::.:|::  :|:.||::||: ..|:.|.:|.||:
Human   103 FHKGEKFQILN--SSEGDWWEARSLTTGETGYIPSNYV--------------------------- 138

  Fly   409 GGAGGGGGNDSMERRNEGNKPAAQSSGQPIERPNLAGKSWYYGAITRSQCDTVLNGHGHD-GDFL 472
                                       .|::  ::..:.||:|.:.|...:..|...|:. |.||
Human   139 ---------------------------APVD--SIQAEEWYFGKLGRKDAERQLLSFGNPRGTFL 174

  Fly   473 IRDSETNMGDYSVSLK----APGRN-KHFRVHVEQN--MYCIGQRKFHSLDQLVDHY-QRA 525
            ||:|||..|.||:|::    ..|.: ||:::....|  .|...:.:|.:|.|||.|| :||
Human   175 IRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERA 235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_722657.1	SH3_Nck_1	154..204	CDD:212699
		SH3_Nck_2	256..308	CDD:212700	12/52 (23%)
		SH3_Nck_3	328..383	CDD:212701	20/55 (36%)
		SH2_Nck_family	446..538	CDD:198196	32/89 (36%)
FYN	NP_002028.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	14..35		5/22 (23%)
		SH3_Fyn_Yrk	85..140	CDD:212939	21/138 (15%)
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281	32/91 (35%)
		PTKc_Fyn	261..534	CDD:270655