Protein Alignment dock and ABL1

DIOPT Version :10

• Sequence 1: NP_722657.1
• Gene: dock / 33262
• FlyBaseID: FBgn0010583
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_009297.2
• Gene: ABL1 / 25
• HGNCID: 76
• Length: 1149
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 73/321 - (22%)
• Similarity: 125/321 - (38%)
• Gaps: 115/321 - (35%)

  Fly   206 KEKPSL--FDSIKKKVKKGSGSKTLPNCSPSRQVESPTMSRRLPPDPAEAIGTAVVKYNYQAQQP 268
            :.:|||  ...||...||.|.....|:|:..  ||...:.|.:..|             ::.|
Human    12 QRRPSLPALHFIKGAGKKESSRHGGPHCNVF--VEHEALQRPVASD-------------FEPQ-- 59

  Fly   269 DELSLTKGTRILILEKSNDGWWRGQSGNSVGWFPSNYTTEDCDNDGEIHTYAMAENVLDIVVALY 333
               .|::..|           |..:.....|  ||                   ||..::.||||
Human    60 ---GLSEAAR-----------WNSKENLLAG--PS-------------------ENDPNLFVALY 89

  Fly   334 SFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARNNQGQVGLVPRNYLQELNDYLATPYRNASAS 398
            .|.::.|..||..||::|.::.. ..:.:|.:|:...|| |.||.||:..:|
Human    90 DFVASGDNTLSITKGEKLRVLGY-NHNGEWCEAQTKNGQ-GWVPSNYITPVN------------- 139

  Fly   399 AGNGNGGGSNGGAGGGGGNDSMERRNEGNKPAAQSSGQPIERPNLAGKSWYYGAITRSQCDTVLN 463
                                |:|:.                       |||:|.::|:..:.:|:
Human   140 --------------------SLEKH-----------------------SWYHGPVSRNAAEYLLS 161

  Fly   464 GHGHDGDFLIRDSETNMGDYSVSLKAPGRNKHFRVHV--EQNMYCIGQRKFHSLDQLVDHY 522
            . |.:|.||:|:||::.|..|:||:..||..|:|::.  :..:|...:.:|::|.:||.|:
Human   162 S-GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHH 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_722657.1	SH3_Nck_1	154..204	CDD:212699
		SH3_Nck_2	256..308	CDD:212700	7/51 (14%)
		SH3_Nck_3	328..383	CDD:212701	20/54 (37%)
		SH2_Nck_family	446..538	CDD:198196	27/79 (34%)
ABL1	NP_009297.2	SH3_Abl	84..137	CDD:212784	20/54 (37%)
		SH2_ABL	142..235	CDD:198189	28/104 (27%)
		PTKc_Abl	254..516	CDD:270645
		FABD	1025..1149	CDD:197885