DRSC/TRiP Functional Genomics Resources

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Protein Alignment dock and CD2AP

DIOPT Version :10

Sequence 1:NP_722657.1 Gene:dock / 33262 FlyBaseID:FBgn0010583 Length:548 Species:Drosophila melanogaster
Sequence 2:NP_036252.1 Gene:CD2AP / 23607 HGNCID:14258 Length:639 Species:Homo sapiens


Alignment Length:349 Identity:68/349 - (19%)
Similarity:120/349 - (34%) Gaps:134/349 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   152 VCYVVAKYDYAAQGAQELDLR-----KNERYLLLDDSKHWWRVQNSRNQSGYVPSNYV---KKEK 208
            |.|:| :|||.|....||.:|     :|.:.|    .:..|.......:.|..|.|:|   |:|.
Human     2 VDYIV-EYDYDAVHDDELTIRVGEIIRNVKKL----QEEGWLEGELNGRRGMFPDNFVKEIKRET 61

  Fly   209 PSLFDSIK-KKVKKGSGSKTLPNCS-------------PSRQVESPTMSRRLPPDPAEAIGTAVV 259
            ....||:. |:.:.|:.:..:...|             .::.::..|..|:           ..|
Human    62 EFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQ-----------CKV 115

  Fly   260 KYNYQAQQPDELSLTKGTRILILEKSNDGWWRGQSGNSVGWFPSNYTTE-DCDNDGEIHTYAMAE 323
            .:.|..|..|||.|..|..|.|.|:..:|||.|...|.:|.||||:..| :..:|||.|.   |:
Human   116 LFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHE---AQ 177

  Fly   324 NVLDIVVA--------------------------------------------------------- 331
            :..:.|:|                                                         
Human   178 DDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPE 242

  Fly   332 ----------------------------------LYSFTSNNDQELSFEKGDRLEIVDRPASDPD 362
                                              |:::...|:.||:|::|:.:.::.:...:..
Human   243 KPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAG 307

  Fly   363 WYKARNNQGQVGLVPRNYLQELND 386
            |::...| |:.|:.|.|:..::|:
Human   308 WWRGELN-GKEGVFPDNFAVQINE 330

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dockNP_722657.1 SH3_Nck_1 154..204 CDD:212699 15/54 (28%)
SH3_Nck_2 256..308 CDD:212700 21/51 (41%)
SH3_Nck_3 328..383 CDD:212701 14/145 (10%)
SH2_Nck_family 446..538 CDD:198196
CD2APNP_036252.1 Interaction with ANLN and localization to the midbody. /evidence=ECO:0000269|PubMed:15800069 1..175 51/188 (27%)
SH3_CD2AP_1 3..58 CDD:212986 16/59 (27%)
SH3_CD2AP_2 111..165 CDD:212987 22/64 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 168..209 7/43 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 227..256 0/28 (0%)
SH3_CD2AP_3 271..327 CDD:212989 12/56 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 333..428
SH3-binding. /evidence=ECO:0000255 336..352
SH3-binding. /evidence=ECO:0000255 378..397
SH3-binding. /evidence=ECO:0000255 410..422
Blue background indicates that the domain is not in the aligned region.

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