Protein Alignment dock and FGR

DIOPT Version :10

• Sequence 1: NP_722657.1
• Gene: dock / 33262
• FlyBaseID: FBgn0010583
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_005239.1
• Gene: FGR / 2268
• HGNCID: 3697
• Length: 529
• Species: Homo sapiens
• Alignment Length: 291
• Identity: 65/291 - (22%)
• Similarity: 110/291 - (37%)
• Gaps: 116/291 - (39%)

  Fly   248 PDPAEAIGTAVVKY--NY-----QAQQPDELSLTKGTRILILEKSNDGWWRGQSGNSVGWFPSNY 305
            |||.:|...:...:  ||     ||..|..|              :.|..||.||..|..|
Human    36 PDPTKARPASSFAHIPNYSNFSSQAINPGFL--------------DSGTIRGVSGIGVTLF---- 82

  Fly   306 TTEDCDNDGEIHTYAMAENVLDIVVALYSFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARN-N 369
                                    :|||.:.:..:.:|:|.||::..|::.  ::.||::||: :
Human    83 ------------------------IALYDYEARTEDDLTFTKGEKFHILNN--TEGDWWEARSLS 121

  Fly   370 QGQVGLVPRNYLQELNDYLATPYRNASASAGNGNGGGSNGGAGGGGGNDSMERRNEGNKPAAQSS 434
            .|:.|.:|.||:
Human   122 SGKTGCIPSNYV----------------------------------------------------- 133

  Fly   435 GQPIERPNLAGKSWYYGAITRSQCDTVLNGHGH-DGDFLIRDSETNMGDYSVSLKAPGRN----- 493
             .|::  ::..:.||:|.|.|...:..|...|: .|.||||:|||..|.||:|::...:.
Human   134 -APVD--SIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHV 195

  Fly   494 KHFRVH-VEQNMYCIGQR-KFHSLDQLVDHY 522
            ||:::. ::...|.|..| :|:|:.:||.||
Human   196 KHYKIRKLDMGGYYITTRVQFNSVQELVQHY 226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_722657.1	SH3_Nck_1	154..204	CDD:212699
		SH3_Nck_2	256..308	CDD:212700	13/58 (22%)
		SH3_Nck_3	328..383	CDD:212701	17/55 (31%)
		SH2_Nck_family	446..538	CDD:198196	30/85 (35%)
FGR	NP_005239.1	SH3	80..137	CDD:473055	19/140 (14%)
		SH2_Src_Fgr	140..240	CDD:198230	30/87 (34%)
		Protein Kinases, catalytic domain	267..514	CDD:473864