DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dock and Sla

DIOPT Version :9

Sequence 1:	NP_001259845.1	Gene:	dock / 33262	FlyBaseID:	FBgn0010583	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_017172011.1	Gene:	Sla / 20491	MGIID:	104295	Length:	320	Species:	Mus musculus

Alignment Length:	199	Identity:	45/199 - (22%)
Similarity:	76/199 - (38%)	Gaps:	66/199 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 DIVVALYSFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARN-NQGQVGLVPRNYLQELNDYLAT 390
            |.:..|..:.|.:.....|.:|::|.::   :.:..|:||.: :.|:...:|       ...:|.
Mouse    64 DFLAVLTDYPSPDISPPIFRRGEKLRVI---SDEGGWWKAISLSTGRESYIP-------GICVAR 118

  Fly   391 PYRNASASAGNGNGGGSNGGAGGGGGNDSMERRNEGNKPAAQSSGQPIERPNLAGKSWYYGAITR 455
            .|               :|....|.|.|..|              :.::.|
Mouse   119 VY---------------HGWLFEGLGRDKAE--------------ELLQLP-------------- 140

  Fly   456 SQCDTVLNGHGHDGDFLIRDSETNMGDYSVSLKAPGRNKHFRV-HVEQNMYCIGQR-KFHSLDQL 518
               ||.:      |.|:||:|||..|.||:|:: ..:.||:|: .:..|.|.|..| .|..|:.|
Mouse   141 ---DTKI------GSFMIRESETKKGFYSLSVR-HRQVKHYRIFRLPNNWYYISPRLTFQCLEDL 195

  Fly   519 VDHY 522
            |.||
Mouse   196 VTHY 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_001259845.1	SH3_Nck_1	154..204	CDD:212699
		SH3_Nck_2	256..308	CDD:212700
		SH3_Nck_3	328..383	CDD:212701	10/55 (18%)
		SH2_Nck_family	446..538	CDD:198196	26/79 (33%)
Sla	XP_017172011.1	SH3_SLAP	65..119	CDD:212943	11/63 (17%)
Sla	XP_017172011.1	SH2_SLAP	112..209	CDD:198207	35/148 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838357
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930