Protein Alignment dock and Nck1

DIOPT Version :10

• Sequence 1: NP_722657.1
• Gene: dock / 33262
• FlyBaseID: FBgn0010583
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_035008.2
• Gene: Nck1 / 17973
• MGIID: 109601
• Length: 377
• Species: Mus musculus
• Alignment Length: 414
• Identity: 179/414 - (43%)
• Similarity: 254/414 - (61%)
• Gaps: 70/414 - (16%)

  Fly   155 VVAKYDYAAQGAQELDLRKNERYLLLDDSKHWWRVQNSRNQSGYVPSNYVKKEKPSLFDSIKKKV 219
            ||||:||.||..||||::||||..||||||.||||:||.|::|:||||||:::..:...||.|.:
Mouse     7 VVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIVKNL 71

  Fly   220 KKGSGSKTLPNCSPSRQVESPTMSRRLPP------DPAEAI----GTAVVKYNYQAQQPDELSLT 274
            |...|.        .:....|::.....|      ||.|.:    ..|.||:||.|::.|||||.
Mouse    72 KDTLGI--------GKVKRKPSVPDTASPADDSFVDPGERLYDLNMPAFVKFNYMAEREDELSLI 128

  Fly   275 KGTRILILEKSNDGWWRGQSGNSVGWFPSNYTTEDCDNDGEIHTYAMAE------------NVLD 327
            |||:::::||.:||||||.....:|||||||.||:.|:....|..:::|            .||.
Mouse   129 KGTKVIVMEKCSDGWWRGSYNGQIGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLH 193

  Fly   328 IVVALYSFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARNNQGQVGLVPRNYLQELNDYLATPY 392
            :|.|||.|:|:||:||:|||||.::::::|.:||:|:|.|...|.|||||:||:        |..
Mouse   194 VVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYV--------TIM 250

  Fly   393 RNASASAGNGNGGGSNGGAGGGGGNDSMERRNEGNKPAAQSSGQPIERPNLAGK----SWYYGAI 453
            :|...::|                       .|.:.|...     ..||:|.||    .||||.:
Mouse   251 QNNPLTSG-----------------------LEPSPPQCD-----YIRPSLTGKFAGNPWYYGKV 287

  Fly   454 TRSQCDTVLNGHGHDGDFLIRDSETNMGDYSVSLKAPGRNKHFRVHVEQNMYCIGQRKFHSLDQL 518
            ||.|.:..||..||:|||||||||::..|:||||||.|:||||:|.:::.:||||||||.::::|
Mouse   288 TRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEEL 352

  Fly   519 VDHYQRAPIYTNKQGEKLYLVRSL 542
            |:||::|||:|::||||||||:.|
Mouse   353 VEHYKKAPIFTSEQGEKLYLVKHL 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_722657.1	SH3_Nck_1	154..204	CDD:212699	34/48 (71%)
		SH3_Nck_2	256..308	CDD:212700	29/51 (57%)
		SH3_Nck_3	328..383	CDD:212701	29/54 (54%)
		SH2_Nck_family	446..538	CDD:198196	55/95 (58%)
Nck1	NP_035008.2	SH3_Nck1_1	3..61	CDD:212833	36/53 (68%)
		SH3_Nck1_2	108..162	CDD:212834	29/53 (55%)
		SH3_Nck1_3	193..249	CDD:212837	29/63 (46%)
		SH2_Nck1	280..376	CDD:198271	57/95 (60%)