DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dock and Nck1

DIOPT Version :9

Sequence 1:	NP_001259845.1	Gene:	dock / 33262	FlyBaseID:	FBgn0010583	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_035008.2	Gene:	Nck1 / 17973	MGIID:	109601	Length:	377	Species:	Mus musculus

Alignment Length:	414	Identity:	179/414 - (43%)
Similarity:	254/414 - (61%)	Gaps:	70/414 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 VVAKYDYAAQGAQELDLRKNERYLLLDDSKHWWRVQNSRNQSGYVPSNYVKKEKPSLFDSIKKKV 219
            ||||:||.||..||||::||||..||||||.||||:||.|::|:||||||:::..:...||.|.:
Mouse     7 VVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIVKNL 71

  Fly   220 KKGSGSKTLPNCSPSRQVESPTMSRRLPP------DPAEAI----GTAVVKYNYQAQQPDELSLT 274
            |...|.        .:....|::.....|      ||.|.:    ..|.||:||.|::.|||||.
Mouse    72 KDTLGI--------GKVKRKPSVPDTASPADDSFVDPGERLYDLNMPAFVKFNYMAEREDELSLI 128

  Fly   275 KGTRILILEKSNDGWWRGQSGNSVGWFPSNYTTEDCDNDGEIHTYAMAE------------NVLD 327
            |||:::::||.:||||||.....:|||||||.||:.|:....|..:::|            .||.
Mouse   129 KGTKVIVMEKCSDGWWRGSYNGQIGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLH 193

  Fly   328 IVVALYSFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARNNQGQVGLVPRNYLQELNDYLATPY 392
            :|.|||.|:|:||:||:|||||.::::::|.:||:|:|.|...|.|||||:||:        |..
Mouse   194 VVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYV--------TIM 250

  Fly   393 RNASASAGNGNGGGSNGGAGGGGGNDSMERRNEGNKPAAQSSGQPIERPNLAGK----SWYYGAI 453
            :|...::|                       .|.:.|...     ..||:|.||    .||||.:
Mouse   251 QNNPLTSG-----------------------LEPSPPQCD-----YIRPSLTGKFAGNPWYYGKV 287

  Fly   454 TRSQCDTVLNGHGHDGDFLIRDSETNMGDYSVSLKAPGRNKHFRVHVEQNMYCIGQRKFHSLDQL 518
            ||.|.:..||..||:|||||||||::..|:||||||.|:||||:|.:::.:||||||||.::::|
Mouse   288 TRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEEL 352

  Fly   519 VDHYQRAPIYTNKQGEKLYLVRSL 542
            |:||::|||:|::||||||||:.|
Mouse   353 VEHYKKAPIFTSEQGEKLYLVKHL 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_001259845.1	SH3_Nck_1	154..204	CDD:212699	34/48 (71%)
		SH3_Nck_2	256..308	CDD:212700	29/51 (57%)
		SH3_Nck_3	328..383	CDD:212701	29/54 (54%)
		SH2_Nck_family	446..538	CDD:198196	55/95 (58%)
Nck1	NP_035008.2	SH3_Nck1_1	3..61	CDD:212833	36/53 (68%)
		SH3_Nck1_2	108..162	CDD:212834	29/53 (55%)
		SH3_Nck1_3	193..249	CDD:212837	29/63 (46%)
		SH2_Nck1	280..376	CDD:198271	57/95 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838359
Domainoid	1	1.000	110	1.000	Domainoid score	I6312
eggNOG	1	0.900	-	-		E1_KOG4226
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38148
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2345
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46567
OrthoDB	1	1.010	-	-		D1097449at2759
OrthoFinder	1	1.000	-	-		FOG0002240
OrthoInspector	1	1.000	-	-		otm42479
orthoMCL	1	0.900	-	-		OOG6_106243
Panther	1	1.100	-	-	LDO	PTHR19969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4150
SonicParanoid	1	1.000	-	-		X1672
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800