Protein Alignment dock and ced-2

DIOPT Version :10

• Sequence 1: NP_722657.1
• Gene: dock / 33262
• FlyBaseID: FBgn0010583
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_500105.1
• Gene: ced-2 / 176968
• WormBaseID: WBGene00000416
• Length: 279
• Species: Caenorhabditis elegans
• Alignment Length: 233
• Identity: 64/233 - (27%)
• Similarity: 107/233 - (45%)
• Gaps: 53/233 - (22%)

  Fly   240 PTMSR----RLPPDPAEAIGTAVVKYNYQAQQPDELSLT-----KGTRI--LILEK---SNDGWW 290
            |.|||    :|..:|..:|||.:::   .:.:|.|.|||     :|..:  .::|:   ..||
 Worm    17 PGMSREEAHKLLGEPQVSIGTFLMR---DSSRPGEYSLTVREADEGNAVCHYLIERGEPKEDG-- 76

  Fly   291 RGQSGNSVGWFPSNYTTEDCD---NDGEIHTY-------AMAENVLDIVVALYSFTSNNDQELSF 345
            ...:|..:    :|.:..|..   |..::...       |..:.::::||..:.||...:.:|.|
 Worm    77 TAAAGVKI----ANQSFPDIPALLNHFKMRVLTEASLLAAYKKPIIEVVVGTFKFTGERETDLPF 137

  Fly   346 EKGDRLEIVDRPASDPDWYKARNNQGQVGLVPRNYLQELNDYLATPYRNASASAGNGNGGGSNGG 410
            |:|:||||:.:  ::.||::|||..|..||||.||:|     :...:.|...|.|...  .|.|.
 Worm   138 EQGERLEILSK--TNQDWWEARNALGTTGLVPANYVQ-----IQMEFHNDRTSKGASQ--SSIGS 193

  Fly   411 AGGGGGNDSMERRNEGNKPAAQSSGQPIE-RPNLAGKS 447
            :|||....|          :|.:|...|| :|.|..|:
 Worm   194 SGGGAERFS----------SASTSSDNIELQPRLPAKA 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_722657.1	SH3_Nck_1	154..204	CDD:212699
		SH3_Nck_2	256..308	CDD:212700	12/61 (20%)
		SH3_Nck_3	328..383	CDD:212701	24/54 (44%)
		SH2_Nck_family	446..538	CDD:198196	1/2 (50%)
ced-2	NP_500105.1	SH2	6..116	CDD:472789	23/107 (21%)
		SH3_Nck_3	120..173	CDD:212701	25/59 (42%)
		SH3	218..274	CDD:473055	1/4 (25%)