DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dock and nck1b

DIOPT Version :9

Sequence 1:	NP_001259845.1	Gene:	dock / 33262	FlyBaseID:	FBgn0010583	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_002666641.1	Gene:	nck1b / 100334953	ZFINID:	ZDB-GENE-090317-1	Length:	381	Species:	Danio rerio

Alignment Length:	408	Identity:	175/408 - (42%)
Similarity:	249/408 - (61%)	Gaps:	56/408 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 VVAKYDYAAQGAQELDLRKNERYLLLDDSKHWWRVQNSRNQSGYVPSNYVKKEKPSLFDSIKKKV 219
            |:||:||.||..||||::||||..||||||.||||:|:.|::|:||||||:::..:...||.|.:
Zfish     7 VIAKFDYMAQQDQELDIKKNERLWLLDDSKSWWRVRNATNKTGFVPSNYVERKNSARKASIVKNL 71

  Fly   220 KKGSGSKTLPNCSPSRQVESPTMSRRLPPDPAEAIG----TAVVKYNYQAQQPDELSLTKGTRIL 280
            |...|...:...:..|:..|...| ...||..|.:.    .|:||::|.|::.|||||.||||::
Zfish    72 KDTLGIGKVKRKTGMRETASNADS-DFYPDNGERLYDLNLPALVKFSYAAEREDELSLVKGTRVI 135

  Fly   281 ILEKSNDGWWRGQSGNSVGWFPSNYTTEDCD----ND--------GEIHTYAMAENVLDIVVALY 333
            ::||.:||||||......|||||||.|||.|    ||        ..:...|....||..|.|||
Zfish   136 VMEKCSDGWWRGSYNGRSGWFPSNYVTEDADGSASNDSAGLSDKLSAVVQSANGNRVLHTVQALY 200

  Fly   334 SFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARNNQGQVGLVPRNYLQELNDYLATPYRNASAS 398
            .|:|.||:||:||||:.:::|::|.:||:|:|.|.:.||:||||:||:..|
Zfish   201 PFSSGNDEELNFEKGEVMDVVEKPENDPEWWKCRKSDGQMGLVPKNYVTVL-------------- 251

  Fly   399 AGNGNGGGSNGGAGGGGGNDSMERRNEGNKPAAQSSG----QPIERPNLAGKSWYYGAITRSQCD 459
                                 .|..|..:.|...:..    :|......|||.||||.:||.|.:
Zfish   252 ---------------------QESHNSASMPGPPTPDCDYIEPSSSGRFAGKQWYYGKVTRHQAE 295

  Fly   460 TVLNGHGHDGDFLIRDSETNMGDYSVSLKAPGRNKHFRVHVEQNMYCIGQRKFHSLDQLVDHYQR 524
            ..||..|.:|||||||||::..|:|:||||..:||||:|.::.|:||||||||:::::||:||::
Zfish   296 VALNQRGSEGDFLIRDSESSPNDFSISLKAQSKNKHFKVQLKDNLYCIGQRKFNTMEELVEHYKK 360

  Fly   525 APIYTNKQGEKLYLVRSL 542
            |||:|::||:|||||::|
Zfish   361 APIFTSEQGDKLYLVKAL 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dock	NP_001259845.1	SH3_Nck_1	154..204	CDD:212699	32/48 (67%)
		SH3_Nck_2	256..308	CDD:212700	29/51 (57%)
		SH3_Nck_3	328..383	CDD:212701	29/54 (54%)
		SH2_Nck_family	446..538	CDD:198196	52/91 (57%)
nck1b	XP_002666641.1	SH3_Nck1_1	3..61	CDD:212833	34/53 (64%)
		SH3_Nck1_2	109..163	CDD:212834	29/53 (55%)
		SH3_Nck1_3	194..250	CDD:212837	29/55 (53%)
		SH2	282..378	CDD:301589	55/95 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582189
Domainoid	1	1.000	107	1.000	Domainoid score	I6441
eggNOG	1	0.900	-	-		E1_KOG4226
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38148
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2346
OMA	1	1.010	-	-		QHG46567
OrthoDB	1	1.010	-	-		D1097449at2759
OrthoFinder	1	1.000	-	-		FOG0002240
OrthoInspector	1	1.000	-	-		otm25815
orthoMCL	1	0.900	-	-		OOG6_106243
Panther	1	1.100	-	-	LDO	PTHR19969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4150
SonicParanoid	1	1.000	-	-		X1672
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800