DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3862 and HERC2

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_004658.3	Gene:	HERC2 / 8924	HGNCID:	4868	Length:	4834	Species:	Homo sapiens

Alignment Length:	420	Identity:	107/420 - (25%)
Similarity:	178/420 - (42%)	Gaps:	72/420 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 RVYVWGFQETGALGLQTNVKKAKERYTEMVHHPTRLQFSNNNEITDVAAGYGFTVYAVNRDDGET 109
            :|:|||..:...||   .:|.:|      :..|:..:..:...:..||.| ..:::||..:.  .
Human  2960 KVFVWGLNDKDQLG---GLKGSK------IKVPSFSETLSALNVVQVAGG-SKSLFAVTVEG--K 3012

  Fly   110 LFGSGLNTDSQLGFQVKGNPNDPANLDVIIYPTAIKLPR-VQGETDEDMRVKSMSAGRAHLVVLT 173
            ::..|..|:.:||..:...              .:.:|| :...:...::..::.:|..|...||
Human  3013 VYACGEATNGRLGLGISSG--------------TVPIPRQITALSSYVVKKVAVHSGGRHATALT 3063

  Fly   174 QNGTIFTLGNNSYGQCGRSIIEEERYSKSALIHRISQEDICGKEDEVVQVECGQDHSMFLTKKGR 238
            .:|.:|:.|....|:.|.  .......|..||..:       |...:..:.||..||..||..|.
Human  3064 VDGKVFSWGEGDDGKLGH--FSRMNCDKPRLIEAL-------KTKRIRDIACGSSHSAALTSSGE 3119

  Fly   239 IYTCGWGADGQTGQGNYHTAGQI------TLIGGDVEKEKIVRLSCSS-DC-VLALNEAGDAFGW 295
            :||.|.|..|:.|.|:..|  |:      .|:|     .::::::|.| |. .|||.:.|..|.|
Human  3120 LYTWGLGEYGRLGHGDNTT--QLKPKMVKVLLG-----HRVIQVACGSRDAQTLALTDEGLVFSW 3177

  Fly   296 GNSEYGQLDDSELAETQINIPRALKLTKSIGKIKDVAAGGSFCMALNDQGLVYTWGFG---ILGF 357
            |:.::|:|...  .....|||:.::.....| :..:..|..|.:||...|:|:|||.|   .||.
Human  3178 GDGDFGKLGRG--GSEGCNIPQNIERLNGQG-VCQIECGAQFSLALTKSGVVWTWGKGDYFRLGH 3239

  Fly   358 GPFVEQTSKPQHLLPPLFGRNDFSNETTVVSIGCGVFHMGAVNSDGDLFMWGKNRFGHLGLGHKK 422
            |..| ...||| ::..|.|:.       :|.:..|..|..||...|.::.||.|..|..|.|...
Human  3240 GSDV-HVRKPQ-VVEGLRGKK-------IVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTT 3295

  Fly   423 DQFFPFKAAING----KVTKVAYGVDHTIA 448
            ....|  ..:.|    |:|:||.|..|::|
Human  3296 VNRKP--TLVQGLEGQKITRVACGSSHSVA 3323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826	12/53 (23%)
		RCC1_2	159..188	CDD:290274	7/28 (25%)
		RCC1	175..233	CDD:278826	13/57 (23%)
		RCC1_2	220..249	CDD:290274	11/28 (39%)
		RCC1	236..286	CDD:278826	16/57 (28%)
		RCC1	290..341	CDD:278826	12/50 (24%)
		RCC1	345..395	CDD:278826	17/52 (33%)
		RCC1_2	386..414	CDD:290274	9/27 (33%)
		RCC1	402..449	CDD:278826	16/51 (31%)
HERC2	NP_004658.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..88
		RCC1 1-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	415..461
		RCC1 1-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	462..512
		RCC1 1-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	513..568
		RCC1	514..566	CDD:278826
		RCC1 1-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	569..620
		RCC1	569..620	CDD:278826
		RCC1 1-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	623..674
		RCC1	623..672	CDD:278826
		RCC1 1-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	675..726
		RCC1	675..724	CDD:278826
		RCC1 1-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	728..778
		Cyt-b5	1209..1282	CDD:278597
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1555..1575
		MIB_HERC2	1870..1929	CDD:284184
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1933..1958
		UBA_HERC2	2460..2507	CDD:270585
		Cul7	2554..2631	CDD:288381
		ZZ_HERC2	2706..2750	CDD:239084
		APC10-HERC2	2765..2910	CDD:176485
		RCC1 2-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	2958..3009		14/58 (24%)
		RCC1	2960..3007	CDD:278826	12/56 (21%)
		RCC1 2-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3010..3064		9/69 (13%)
		RCC1	3010..3062	CDD:278826	8/67 (12%)
		RCC1 2-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3065..3116		14/59 (24%)
		RCC1	3065..3114	CDD:278826	13/57 (23%)
		RCC1	3117..3168	CDD:278826	16/57 (28%)
		RCC1 2-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3118..3168		16/56 (29%)
		RCC1 2-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3171..3222		14/53 (26%)
		RCC1	3171..3220	CDD:278826	12/51 (24%)
		RCC1	3223..3272	CDD:278826	18/57 (32%)
		RCC1 2-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3224..3274		20/58 (34%)
		RCC1 2-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3275..3326		16/51 (31%)
		RCC1	3275..3324	CDD:278826	16/51 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3602..3629
		RCC1 3-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3951..4002
		RCC1 3-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4004..4056
		RCC1_2	4039..4069	CDD:290274
		RCC1	4057..4106	CDD:278826
		RCC1 3-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4058..4108
		RCC1 3-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4110..4162
		RCC1	4110..4160	CDD:278826
		RCC1	4163..4212	CDD:278826
		RCC1 3-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4164..4214
		RCC1	4215..4263	CDD:278826
		RCC1 3-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4216..4266
		RCC1	4267..4316	CDD:278826
		RCC1 3-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4268..4318
		HECTc	4421..4792	CDD:238033
		HECTc	4464..4790	CDD:214523
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4804..4834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820