DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and HERC3

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_055421.1	Gene:	HERC3 / 8916	HGNCID:	4876	Length:	1050	Species:	Homo sapiens

Alignment Length:	332	Identity:	93/332 - (28%)
Similarity:	154/332 - (46%)	Gaps:	33/332 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 GFQVKGNPNDPANLDVIIYPTAIKLPRVQGETDEDMRVKSMSAGRAHLVVLTQNGTIFTLGNNSY 186
            |:...|.|....||..|:..     |:|.|.. .|..||.::.|..|.|.|.::|.::|.|.|:.
Human     5 GYWSLGQPGISTNLQGIVAE-----PQVCGFI-SDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63

  Fly   187 GQCGRSIIEEERYSKSALIHRISQEDICGKEDEVVQVECGQDHSMFLTKKGRIYTCGWGADGQTG 251
            ||.|    .|...:|...|..::       :..::.|.||:.||:.|:.:|::::.|.|:|||.|
Human    64 GQLG----HEREGNKPEQIGALA-------DQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLG 117

  Fly   252 QGNYHTAGQITLIGGDVEKEKIVRLSCSSDCVLALNEAGDAFGWGNSEYGQLDDSELAETQINIP 316
            ......:..:..:...:.::.|:::||.:...|||...|..|.||.:.:|||...:...:|.: |
Human   118 LMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS-P 181

  Fly   317 RALKLTKSIGKIKDVAAGGSFCMALNDQGLVYTWGF---GILGFGPFVEQTSKPQHLLPPLFGRN 378
            :.::..:.| .:..|||||:...||:..|.|:.||.   |.||.....::.| |.|:
Human   182 QRVRSLEGI-PLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRES-PCHV-------- 236

  Fly   379 DFSNETTVVSIGCGVFHMGAVNSDGDLFMWGKNRFGHLGLGHKKDQFFPFKA--AINGKVTKVAY 441
            .......||.|.||..|...:...|.:|.:|....|.||.....|:..|.:.  .:..:||::|.
Human   237 KLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIAC 301

  Fly   442 GVDHTIA 448
            |..||:|
Human   302 GRQHTLA 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826
		RCC1_2	159..188	CDD:290274	10/28 (36%)
		RCC1	175..233	CDD:278826	15/57 (26%)
		RCC1_2	220..249	CDD:290274	10/28 (36%)
		RCC1	236..286	CDD:278826	11/49 (22%)
		RCC1	290..341	CDD:278826	15/50 (30%)
		RCC1	345..395	CDD:278826	15/52 (29%)
		RCC1_2	386..414	CDD:290274	9/27 (33%)
		RCC1	402..449	CDD:278826	15/49 (31%)
HERC3	NP_055421.1	RCC1 1	1..51		16/51 (31%)
		ATS1	2..331	CDD:227511	93/332 (28%)
		RCC1 2	52..101		16/59 (27%)
		RCC1 3	102..154		13/51 (25%)
		RCC1 4	156..207		17/52 (33%)
		RCC1 5	208..259		16/59 (27%)
		RCC1 6	261..311		15/48 (31%)
		RCC1	313..377	CDD:366085
		RCC1 7	313..366
		HECTc	702..1048	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920