DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and SRM1

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_011418.1	Gene:	SRM1 / 852782	SGDID:	S000003065	Length:	482	Species:	Saccharomyces cerevisiae

Alignment Length:	437	Identity:	105/437 - (24%)
Similarity:	169/437 - (38%)	Gaps:	126/437 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LAQDKSKIKEYSPKTTDS----HEHRVYVWGFQETGALGLQTNVKKAKERYTEMVHHPTRLQFSN 84
            |.:|::||..::.....:    .|..|:.||..:.||||..|:  .|||:..:|     ....|:
Yeast    79 LPRDEAKIISFAVGGMHTLALDEESNVWSWGCNDVGALGRDTS--NAKEQLKDM-----DADDSS 136

  Fly    85 NNEITD------------------VAAGYGFTVYAVNRDDGETLFGSG--------LNTDSQLGF 123
            ::|..|                  :|.|:.....|...:....||.:|        ...:..|||
Yeast   137 DDEDGDLNELESTPAKIPRESFPPLAEGHKVVQLAATDNMSCALFSNGEVYAWGTFRCNEGILGF 201

  Fly   124 -QVKGNPNDPANLDVIIYPTAIKLPRVQGETDEDMRVKSMSAGRAHLVVLTQNGTIFTLGNNSYG 187
             |.|          :.|..|..|:|     |.....:..::.|:.|::.|.:.|.:|..||....
Yeast   202 YQDK----------IKIQKTPWKVP-----TFSKYNIVQLAPGKDHILFLDEEGMVFAWGNGQQN 251

  Fly   188 QCGRSIIEEERYS-----KSALIHRISQEDICGKEDEVVQVECGQDHSMFLTKKGRIYTCGWGAD 247
            |.||.::|..|..     ...|.|             |..:..|::|...|||..::.:.|....
Yeast   252 QLGRKVMERFRLKTLDPRPFGLRH-------------VKYIASGENHCFALTKDNKLVSWGLNQF 303

  Fly   248 GQTGQGNYHTAGQITLIGGDVEKEKIV----RLSCSSDCV-----------LALNEAGDAFGWGN 297
            ||.|            :..|||...:|    ||:...:.|           |.|::.||.:
Yeast   304 GQCG------------VSEDVEDGALVTKPKRLALPDNVVIRSIAAGEHHSLILSQDGDLY---- 352

  Fly   298 SEYGQLDDSELAETQINIP-----------RALKL-TK--SIGKIKDVAAGGSFCMALNDQGLVY 348
             ..|:||..|:...:.|:|           ||:.| ||  ::.|.|.||||....:|:...|:.|
Yeast   353 -SCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLNNVPKFKSVAAGSHHSVAVAQNGIAY 416

  Fly   349 TWGFG---ILGFGPFVEQTSKPQHLLPPLFGRNDFSNETTVVSIGCG 392
            :||||   .:|.|||.:.|..|..:      :|..:.:..::.:|||
Yeast   417 SWGFGETYAVGLGPFEDDTEVPTRI------KNTATQDHNIILVGCG 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826	18/73 (25%)
		RCC1_2	159..188	CDD:290274	7/28 (25%)
		RCC1	175..233	CDD:278826	14/62 (23%)
		RCC1_2	220..249	CDD:290274	7/28 (25%)
		RCC1	236..286	CDD:278826	12/64 (19%)
		RCC1	290..341	CDD:278826	19/64 (30%)
		RCC1	345..395	CDD:278826	16/51 (31%)
		RCC1_2	386..414	CDD:290274	3/7 (43%)
		RCC1	402..449	CDD:278826
SRM1	NP_011418.1	ATS1	15..477	CDD:227511	105/437 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900