DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and EEA1

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_011537116.1	Gene:	EEA1 / 8411	HGNCID:	3185	Length:	1453	Species:	Homo sapiens

Alignment Length:	350	Identity:	66/350 - (18%)
Similarity:	120/350 - (34%)	Gaps:	106/350 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ISRSYTAKAKRGVLAQDKSKIKEYSPKTTDSHEHRVYVWGFQETGALGLQTNVKKAKERYTEMVH 75
            :.|.:...:::|...|   |:||...:....::|              |:...|:.:::..|...
Human   402 LHRIHVELSEKGEATQ---KLKEELSEVETKYQH--------------LKAEFKQLQQQREEKEQ 449

  Fly    76 HPTRLQFSNNNEITDVAAGYGFTVYAVNRDDGETLFGSGLNTDSQLGFQVKGNPNDPANL----- 135
            |..:||...|.                       |....|.|:.||| :..|...:...|
Human   450 HGLQLQSEINQ-----------------------LHSKLLETERQLG-EAHGRLKEQRQLSSEKL 490

  Fly   136 ---DVIIYPTAIKLPRVQGETDEDMRVKSMSAGRAHLVVLT----------QNGTIFTL--GNNS 185
               :..:....:||.|::.:..|.:   :.|....|.:..|          |..|...|  ..|.
Human   491 MDKEQQVADLQLKLSRLEEQLKEKV---TNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQND 552

  Fly   186 YGQCGRSIIEEER--YSKSALIHRISQEDIC----GKEDEVVQVECGQ------------DHSM- 231
            ..|..|.|.::::  .:..||:.: |:|:|.    .:||...:::.|:            :|::
Human   553 LEQVLRQIGDKDQKIQNLEALLQK-SKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ 616

  Fly   232 ----FLTKKGRIYTCGWGADGQTGQGNYHTAGQITLIGGDVEKEKIVRLSCSSDCVLAL----NE 288
                .||:|.:            .|...|...|..|  .|..:|:...|..:.|.||:|    ||
Human   617 EQVTQLTEKLK------------NQSESHKQAQENL--HDQVQEQKAHLRAAQDRVLSLETSVNE 667

  Fly   289 AGDAFGWGNSEYGQLDDSELAETQI 313
            ..........:..|||....|:|::
Human   668 LNSQLNESKEKVSQLDIQIKAKTEL 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826	8/55 (15%)
		RCC1_2	159..188	CDD:290274	7/40 (18%)
		RCC1	175..233	CDD:278826	15/82 (18%)
		RCC1_2	220..249	CDD:290274	5/45 (11%)
		RCC1	236..286	CDD:278826	11/49 (22%)
		RCC1	290..341	CDD:278826	5/23 (22%)
		RCC1	345..395	CDD:278826
		RCC1_2	386..414	CDD:290274
		RCC1	402..449	CDD:278826
EEA1	XP_011537116.1	Myosin_tail_1	308..1382	CDD:279860	66/349 (19%)
		DUF342	<425..519	CDD:302792	20/134 (15%)
		FYVE_EEA1	1389..1451	CDD:277269
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900