DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and Rcc1

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_006239135.1	Gene:	Rcc1 / 682908	RGDID:	1592835	Length:	434	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	120/482 - (24%)
Similarity:	187/482 - (38%)	Gaps:	108/482 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AKRGVLAQD----KSKIKEY-----SPKTTD-SHEHR------VYVWGFQETGALGLQTNVKKAK 67
            |||....:|    ..|:|:.     :|::.. ||...      |...|..:.|.|||..:|.:.|
  Rat     7 AKRRSPPEDAIPKSKKVKDTRNRRPAPRSCQVSHRSHNTEPGLVLTLGQGDVGQLGLGESVLERK 71

  Fly    68 ERYTEMVHHPTRLQFSNNNEITDVAAGYGFTVYAVNRDDGETLFGSGLNTDSQLG--FQVKGNPN 130
            :        |..:..     :.||.......::.|.......::..|.|.:..||  ..|:|:
  Rat    72 K--------PALVPL-----LQDVVQAEAGGMHTVCLSQSGQVYSFGCNDEGALGRDTSVEGS-- 121

  Fly   131 DPANLDVIIYPTAIKLPRVQGETDEDMRVKSMSAGRAHLVVLTQNGTIFTLGN--NSYGQCGRSI 193
                            ..|.|:.:...:|..:|||.:|...||::|.:|..|:  ::.|..|  :
  Rat   122 ----------------EMVPGKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIG--L 168

  Fly   194 IEEERYSKSALIHRISQEDICGKEDEVVQVECGQDHSMFLTKKGRIYTCGWGADGQTGQGNYHTA 258
            :|.   .|.:::....|.|     .:||:|..|.||.:.||..|.:||.|.|..||.|:.....|
  Rat   169 LEP---MKKSMVPVQVQLD-----TQVVKVASGNDHLVMLTTDGDLYTLGCGEQGQLGRVPELFA 225

  Fly   259 GQITLIGGDVEKEKI----------------VRLS---CSSDCVLALNEAGDAFGWGNSEYGQLD 304
            .:    ||....|::                ||..   |.:....|::..|..:|:|.|.|.||.
  Rat   226 NR----GGRQGLERLLVPRCVLLKSRGTRGRVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLG 286

  Fly   305 DSELAETQI--NIPRALKLTKS-IGKIKDVAAGGSFCMALNDQGLVYTWG---FGILGFGPFVEQ 363
            ........|  |:......||| :|    .:.|....:.::.:|..|:.|   :|.||.|...|:
  Rat   287 TPGTGSCFIPQNLTSFKNSTKSWVG----FSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEE 347

  Fly   364 TSKPQHLLPPLFGRNDFSNETTVVSIGCGVFHMGAVNSDGDLFMWGKNRFGHLGLGHKKDQFFPF 428
            .|     :|.|..|     ...|.|:.||.....||:.||.:|.||......||.|.:.|.:.|.
  Rat   348 KS-----IPTLISR-----LPVVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQEDDAWSPV 402

  Fly   429 ----KAAINGKVTKVAYGVDHTIALCK 451
                |...|.:|..|:.|..||:.|.|
  Rat   403 EMTGKQLENREVLTVSSGGQHTVLLVK 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826	11/61 (18%)
		RCC1_2	159..188	CDD:290274	10/30 (33%)
		RCC1	175..233	CDD:278826	15/59 (25%)
		RCC1_2	220..249	CDD:290274	13/28 (46%)
		RCC1	236..286	CDD:278826	15/68 (22%)
		RCC1	290..341	CDD:278826	14/53 (26%)
		RCC1	345..395	CDD:278826	16/52 (31%)
		RCC1_2	386..414	CDD:290274	11/27 (41%)
		RCC1	402..449	CDD:278826	17/50 (34%)
Rcc1	XP_006239135.1	ATS1	19..432	CDD:227511	116/470 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910