DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and RPGR

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001030025.1	Gene:	RPGR / 6103	HGNCID:	10295	Length:	1152	Species:	Homo sapiens

Alignment Length:	349	Identity:	91/349 - (26%)
Similarity:	142/349 - (40%)	Gaps:	79/349 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 MSAGRAHLVVLTQNGTIFTLGNNSYGQCGRSIIEEERYSKSALIHRISQEDICG---KEDEVVQV 223
            :|.|..|..|:|.|..::..|:|::||.|..       ||||:     .:..|.   |.::|...
Human    40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLG-------SKSAI-----SKPTCVKALKPEKVKLA 92

  Fly   224 ECGQDHSMFLTKKGRIYTCGWGADGQTGQGNYHTAGQITLIGGDVEKEKIVRLSCSSDCVLALNE 288
            .||::|::..|:.|.:|..|...:||.|.|:........:|.....:.||.:||..|:...||.|
Human    93 ACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTE 157

  Fly   289 AGDAFGWGNSEYGQL----------------------------------DDSEL------AETQI 313
            .|..|.||::..||:                                  .|.||      ...::
Human   158 DGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222

  Fly   314 NIPRAL-------KLTKSI-GKIKDVAAGGSFCMALNDQGLVYTWG---FGILGFGPFVEQTSKP 367
            .:|..|       :|...| .|:..||.||...:.|.:.. |||:|   ||.||.|.|:.:||:|
Human   223 GLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEP 286

  Fly   368 QHLLPPLFGRNDFSNETTVVSIGCGVFHMGAVNSDGDLFMWGKNRFGHLGLGHKK--DQFFPFKA 430
            :.:        :...:.|:..|.||..|...:...|.::.:|..|.|.||||.:.  :.|.|...
Human   287 KVI--------ENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLC 343

  Fly   431 A--INGKVTKVAYGVDHTIALCKP 452
            :  :...|..||.|..|.:....|
Human   344 SNFLRFIVKLVACGGCHMVVFAAP 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826
		RCC1_2	159..188	CDD:290274	8/25 (32%)
		RCC1	175..233	CDD:278826	16/60 (27%)
		RCC1_2	220..249	CDD:290274	8/28 (29%)
		RCC1	236..286	CDD:278826	13/49 (27%)
		RCC1	290..341	CDD:278826	18/98 (18%)
		RCC1	345..395	CDD:278826	17/52 (33%)
		RCC1_2	386..414	CDD:290274	7/27 (26%)
		RCC1	402..449	CDD:278826	15/50 (30%)
RPGR	NP_001030025.1	RCC1	<38..312	CDD:332518	75/292 (26%)
RPGR	NP_001030025.1	RCC1	314..360	CDD:306840	14/45 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010