DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and RCC2

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001129676.1	Gene:	RCC2 / 55920	HGNCID:	30297	Length:	522	Species:	Homo sapiens

Alignment Length:	380	Identity:	91/380 - (23%)
Similarity:	151/380 - (39%)	Gaps:	111/380 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 MRVKSMSAG--RAHLVVLTQNGTIFTLGNNSYGQCGRSIIEEERYSKSALIHRISQEDICGKEDE 219
            :||:::.:|  .||.:::|..|.:::.|.|..||.|..  :.:|.....||..:|.|       .
Human   148 VRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHG--DTKRVEAPRLIEGLSHE-------V 203

  Fly   220 VVQVECGQDHSMFLTKKGRIYTCGWGADGQTGQGNYHTA----GQITLIGGDVEKEKIVRLSCSS 280
            :|...||::|::.||:.|.::..|....||.|.||...|    .||...|     :.|.:::|.:
Human   204 IVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNG-----QPITKMACGA 263

  Fly   281 DCVLALNEAGDAFGWGNSEYGQLD----------------DSELAETQINIPRALKLTKSIGKI- 328
            :..:.::..|:.:.:|..|||||.                |.||...::.|  .::.||. |:|
Human   264 EFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAI--FIEKTKD-GQIL 325

  Fly   329 -------KDVAAGGSFCMALNDQGLVYTWGFGILGFGPFVEQTSKPQHLLPPLFGRNDFSN---- 382
                   :|||.|.:..:.|:.|..|::||||  |:|.......|.: ::|.|....||..
Human   326 PVPNVVVRDVACGANHTLVLDSQKRVFSWGFG--GYGRLGHAEQKDE-MVPRLVKLFDFPGRGAS 387

  Fly   383 --------ETTVVSIGCGVFHMGAVN---------------------------------SDGDLF 406
                    ...|..:| |:|..||.|                                 :|....
Human   388 QIYAGYTCSFAVSEVG-GLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI 451

  Fly   407 MWGKN-RFGHLGLGHKKDQFFPFKAAINGKVTK---------VAYGVDHTIALCK 451
            .||.: .||.||.|..|.     |::...:..|         ||.|..|::.:.:
Human   452 SWGPSPTFGELGYGDHKP-----KSSTAAQEVKTLDGIFSEQVAMGYSHSLVIAR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826
		RCC1_2	159..188	CDD:290274	8/30 (27%)
		RCC1	175..233	CDD:278826	15/57 (26%)
		RCC1_2	220..249	CDD:290274	8/28 (29%)
		RCC1	236..286	CDD:278826	13/53 (25%)
		RCC1	290..341	CDD:278826	19/74 (26%)
		RCC1	345..395	CDD:278826	15/61 (25%)
		RCC1_2	386..414	CDD:290274	10/61 (16%)
		RCC1	402..449	CDD:278826	15/56 (27%)
RCC2	NP_001129676.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..83
		RCC1 1	103..165		5/16 (31%)
		ATS1	<151..481	CDD:227511	85/355 (24%)
		RCC1 2	168..219		16/59 (27%)
		RCC1 3	221..271		13/54 (24%)
		RCC1 4	273..347		20/76 (26%)
		Required for interaction with RAC1. /evidence=ECO:0000269\|PubMed:28869598	318..325		3/7 (43%)
		RCC1 5	348..401		14/55 (25%)
		RCC1 6	403..447		6/44 (14%)
		RCC1 7	448..501		14/57 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..522		91/380 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910