DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and HERC6

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_005263140.1	Gene:	HERC6 / 55008	HGNCID:	26072	Length:	1034	Species:	Homo sapiens

Alignment Length:	307	Identity:	90/307 - (29%)
Similarity:	144/307 - (46%)	Gaps:	43/307 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 SAGRAHLVVLTQNGTIFTLGNNSYGQCGRSIIEEERYSKSALIH----RISQEDICGKEDEVVQ- 222
            ::|..|.::|..|..:.:.|:||.||.||.  ..:|.....::.    ...:|.|...|..:|.
Human    29 ASGERHSLLLLTNHRVLSCGDNSRGQLGRR--GAQRGELPVVVGGCFVLFPKEPIQALETLIVDL 91

  Fly   223 VECGQDHSMFLTKKGRIYTCGWGADGQTGQGNY----HTAGQITLIGGDVEKEKIVRLSCSSDCV 283
            |.||::||:.:..|||::..|.|::||.|.|.:    .|..:|..: .|:   ||:::||.....
Human    92 VSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTL-NDI---KIIQVSCGHYHS 152

  Fly   284 LALNEAGDAFGWGNSEYGQLDDSELAETQINIPRALKLTKSIGKIKDVAAGGSFCMALNDQGLVY 348
            |||::....|.||.:.:|||...:...:|.: |:.::..:.| .:..|||||:...||:..|..:
Human   153 LALSKDSQVFSWGKNSHGQLGLGKEFPSQAS-PQRVRSLEGI-PLAQVAAGGAHSFALSLCGTSF 215

  Fly   349 TWGFGILGFGPFVEQTSKPQHLLPPLFGRN--DFSNETT---------VVSIGCGVFHMGAVNSD 402
            .||....|      |.:        |.|||  ..||:..         ||.|.||..|...:..|
Human   216 GWGSNSAG------QLA--------LSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQD 266

  Fly   403 GDLFMWGKNRFGHLGLGHKKDQFFP-FKAAINGKVTKVAYGVDHTIA 448
            |.:|.:|.||.|.||.....::..| ....|:|.|:::..|..||:|
Human   267 GKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYHTLA 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826
		RCC1_2	159..188	CDD:290274	7/24 (29%)
		RCC1	175..233	CDD:278826	18/62 (29%)
		RCC1_2	220..249	CDD:290274	11/29 (38%)
		RCC1	236..286	CDD:278826	17/53 (32%)
		RCC1	290..341	CDD:278826	14/50 (28%)
		RCC1	345..395	CDD:278826	16/60 (27%)
		RCC1_2	386..414	CDD:290274	12/27 (44%)
		RCC1	402..449	CDD:278826	17/48 (35%)
HERC6	XP_005263140.1	RCC1_2	27..54	CDD:290274	7/24 (29%)
		RCC1_2	89..118	CDD:290274	11/28 (39%)
		RCC1	105..155	CDD:278826	17/53 (32%)
		RCC1	158..208	CDD:278826	14/51 (27%)
		RCC1	215..263	CDD:278826	16/61 (26%)
		RCC1_2	250..279	CDD:290274	12/28 (43%)
		RCC1	266..313	CDD:278826	16/46 (35%)
		HECTc	684..1026	CDD:238033
		HECTc	711..1026	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920