DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and HERC5

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_011530324.2	Gene:	HERC5 / 51191	HGNCID:	24368	Length:	1100	Species:	Homo sapiens

Alignment Length:	406	Identity:	98/406 - (24%)
Similarity:	151/406 - (37%)	Gaps:	113/406 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VWGFQETGALGLQTNVKKAKERYTEMVHHPTRLQFSNNNEITDVAAGYGFTVYAVNRDDGETLFG 112
            :|.|  ..|.||...:.:..|...::...|.||.....       .|.|..|:       :.|.|
Human   184 LWLF--PSAAGLHRALLRRVEVTRQLCCSPGRLAVLER-------GGAGVQVH-------QLLAG 232

  Fly   113 SGLNTDSQLGFQVKGNPNDPANLDVIIYPTAIKLPRVQGETDEDMRVKSMSAGRAHLVVLTQNGT 177
            ||       |.:.               |..|||       .::|::.|:..|..|:::|:.:|.
Human   233 SG-------GART---------------PKCIKL-------GKNMKIHSVDQGAEHMLILSSDGK 268

  Fly   178 IFTLGNNSYGQCGRSIIEEERYSKSALIHRISQEDICGKEDEVVQVECGQDHSMFLTKKGRIYTC 242
            .|               |.:.||    :..:..|.|. :|.:::|:.||..||:.|:|.|.::..
Human   269 PF---------------EYDNYS----MKHLRFESIL-QEKKIIQITCGDYHSLALSKGGELFAW 313

  Fly   243 GWGADGQTGQGNYHTAGQITLIGGDVEKEKIVRLSCSSDCVLALNEAGDAFGWGNSEYGQL---- 303
            |....||.|.|....:.....|...:....:.::|......:||:.:|:.:.||.:|.|||
Human   314 GQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGH 378

  Fly   304 ----DDSELAETQINIPRALKLTKSIGKIKDVAAGGSFCMALNDQGLVYTWGFGILGFGPFVEQT 364
                ||..|.|...|           .|::.||.|||....|...||::|:|.|..|
Human   379 TESKDDPSLIEGLDN-----------QKVEFVACGGSHSALLTQDGLLFTFGAGKHG-------- 424

  Fly   365 SKPQHLLPPLFGRNDFSNET-----------TVVSIGCGVFHMGAVNSD-GDLFMWGKNRFGHLG 417
                     ..|.|...||.           .|..|.||.:|..|..|| |.:|.:|..:.|.||
Human   425 ---------QLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLG 480

  Fly   418 LGHKKDQFFPFKAAIN 433
            .|..:||..|....::
Human   481 NGGTRDQLMPLPVKVS 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826	11/50 (22%)
		RCC1_2	159..188	CDD:290274	6/28 (21%)
		RCC1	175..233	CDD:278826	13/57 (23%)
		RCC1_2	220..249	CDD:290274	9/28 (32%)
		RCC1	236..286	CDD:278826	8/49 (16%)
		RCC1	290..341	CDD:278826	18/58 (31%)
		RCC1	345..395	CDD:278826	14/60 (23%)
		RCC1_2	386..414	CDD:290274	11/28 (39%)
		RCC1	402..449	CDD:278826	11/33 (33%)
HERC5	XP_011530324.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010