DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and rcc1

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_998343.1	Gene:	rcc1 / 406457	ZFINID:	ZDB-GENE-040426-2216	Length:	418	Species:	Danio rerio

Alignment Length:	477	Identity:	118/477 - (24%)
Similarity:	193/477 - (40%)	Gaps:	116/477 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KRGVLAQDKSKIKEYSPKTTDSHEHR---VYVWGFQETGALGLQTNVKKAKERYTEMVHHPTRLQ 81
            ||...|...|.:.:....:..||...   |.|.|..:.|.|||..:|.:.|:  ..:|..|..:
Zfish     8 KRQTAAPSDSTVAKKLKVSHISHGQEKGLVLVLGQGDVGQLGLGEDVMERKK--PALVTLPEGI- 69

  Fly    82 FSNNNEITDVAAGYGFTVYAVNRDDGETLFGSGLNTDSQLGFQV--KGNPNDPANLDVIIYPTAI 144
                  :..||.|    ::.|...|...::..|.|.:..||...  :|:...||.:|:
Zfish    70 ------VQAVAGG----MHTVCLSDTGNVYTFGCNDEGALGRDTSEEGSETVPAKVDL------- 117

  Fly   145 KLPRVQGETDEDMRVKSMSAGRAHLVVLTQNGTIFTLGN--NSYGQCGRSIIEEERYSKSALIHR 207
                  ||     ::..:|||.:|...||::|.::..|:  ::.|..|             |:..
Zfish   118 ------GE-----KIIQVSAGDSHSAALTEDGGVYVWGSFRDNNGVIG-------------LLEP 158

  Fly   208 ISQEDICGK---EDEVVQVECGQDHSMFLTKKGRIYTCGWGADGQTGQGNYHTAGQITLIGGDVE 269
            :.:..:..|   :..||::..|.||.:.||..|.:||.|.|..||.|:...|.|.:    ||
Zfish   159 MKKCTVPVKVPIDKPVVKIVSGNDHLVMLTAHGELYTSGCGEQGQLGRVAEHFANR----GG--- 216

  Fly   270 KEKIVRL-------------------SCSSDCVLALNEAGDAFGWGNSEYGQLDDSELAETQIN- 314
            ::.::||                   .|.:....|:::.|..:|:|.|.|.||.      ||..
Zfish   217 RKGLMRLLEPQMVIIKPRGKVVFTDVFCGAYFTFAVSKEGHVYGFGLSNYHQLG------TQSTN 275

  Fly   315 ---IPRALKLTKS-----IGKIKDVAAGGSFCMALNDQGLVYTWG---FGILGFGPFVEQTSKPQ 368
               :|..|...|:     :|    .:.|....:.||.:|..|:.|   :|.||.|..|.:.|:|.
Zfish   276 TCFVPVKLSSFKNSTTSWVG----FSGGQHHTLCLNSEGKAYSLGRAEYGRLGLGKDVGEKSEPT 336

  Fly   369 HLLPPLFGRNDFSNETTVVSIGCGVFHMGAVNSDGDLFMWGKNRFGHLGLGHKKDQFFPF----K 429
             ::|.:       ::..||:.|..|.:  ||...|.:|.||......||.|.::|::.|.    |
Zfish   337 -VVPGI-------SDVQVVACGASVSY--AVTKQGSVFSWGMGTNLQLGTGEEEDEWSPVEMTGK 391

  Fly   430 AAINGKVTKVAYGVDHTIALCK 451
            ...|..|..|:.|..||:.|.|
Zfish   392 QLENRVVLSVSSGGQHTVLLVK 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826	14/58 (24%)
		RCC1_2	159..188	CDD:290274	8/30 (27%)
		RCC1	175..233	CDD:278826	11/62 (18%)
		RCC1_2	220..249	CDD:290274	12/28 (43%)
		RCC1	236..286	CDD:278826	15/68 (22%)
		RCC1	290..341	CDD:278826	14/59 (24%)
		RCC1	345..395	CDD:278826	15/52 (29%)
		RCC1_2	386..414	CDD:290274	10/27 (37%)
		RCC1	402..449	CDD:278826	16/50 (32%)
rcc1	NP_998343.1	ATS1	3..415	CDD:227511	118/477 (25%)
		RCC1	34..82	CDD:278826	15/60 (25%)
		RCC1	86..134	CDD:278826	14/65 (22%)
		RCC1	137..187	CDD:278826	11/62 (18%)
		RCC1	191..252	CDD:278826	15/67 (22%)
		RCC1	255..306	CDD:278826	14/60 (23%)
		RCC1	309..357	CDD:278826	15/57 (26%)
		RCC1	361..411	CDD:278826	16/49 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820