DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and rcc2

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_998341.1	Gene:	rcc2 / 406455	ZFINID:	ZDB-GENE-040426-2213	Length:	495	Species:	Danio rerio

Alignment Length:	538	Identity:	120/538 - (22%)
Similarity:	191/538 - (35%)	Gaps:	163/538 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLGISRSYTAKAKRGVLAQDKSKIKEYSPKTT-DSHEHRVYVWGFQETGALGLQ----------- 60
            |..:|.:...|.|||   ..|.|.:|:|.... |.:|........:.....|||
Zfish     6 VTDVSGNGGLKRKRG---GGKKKEREFSSDDEFDDYEQENTKKPGKPAAKAGLQPVTVADDVKEK 67

  Fly    61 --TNVKKAKERYTEMVHHPTRLQFSNNNEITDVAAGYGFTVYAVNRDDGETLFGS---GLNTDSQ 120
              ..|.|.|.:.  ::...|........|:....|.:        |:.|:.|:|.   |..:|.|
Zfish    68 IKLEVPKVKGQL--LIFGATNWDLIGRKEVPKQQAAF--------RNLGQNLWGPHRYGCLSDVQ 122

  Fly   121 LGFQVKGNPNDPANLDVIIYPTAIKLPRVQGETDEDMRVKSMSAGRAHLVVLTQNGTIFTLGNNS 185
            :...|.|             |.|                       ||.:::|..|.:::.|.|.
Zfish   123 VSCVVSG-------------PCA-----------------------AHSLIITTEGKLWSWGRND 151

  Fly   186 YGQCGRSIIEEERYSKSALIHRISQEDICGKEDEVVQVECGQDHSMFLTKKGRIYTCGWGADGQT 250
            .||.|..  :.:|.....||..:.       |:.:|...||::|::.||:.|.:||.|....||.
Zfish   152 KGQLGHG--DTKRLEAPKLIEGLG-------EEVIVAAACGRNHTLALTENGTVYTFGENKLGQL 207

  Fly   251 GQGNYHTAGQITLIGGDVEKEKIVRLSCSSDCVLALNEAGDAFGWGNSEYGQL----DDSELAET 311
            |||| .|...::........:.||:::|.::..:.::..|:.:.:|..|||||    |...:|..
Zfish   208 GQGN-QTDAVLSPATIQYNGQPIVKVACGAEFSMIVDCKGNLYSFGCPEYGQLGHNSDGKFIARA 271

  Fly   312 Q-IN-----IPRALKL----TKSIGKI--------KDVAAGGSFCMALNDQGLVYTWGFGILGFG 358
            | |.     |||.:.:    ||. |::        :|||.|.:..:.|:.|..|::||||  |:|
Zfish   272 QRIEFDCELIPRRVAIFIEKTKD-GQVLPVPNVVARDVACGANHTLVLDSQKRVFSWGFG--GYG 333

  Fly   359 PFVEQTSKPQHLLPPLFGRNDFSNETTVVSIGCGVFHMGAVNSDGDLFMWGKNR----------- 412
            .......|.: ::|.|....||... ....|.||.....|::..|.||.||...
Zfish   334 RLGHAEQKDE-MVPRLVKLFDFPGR-GATQIYCGYQCSFALSEMGGLFFWGVTNTSRESTMYPKA 396

  Fly   413 -----------------------------------FGHLGLGHKKDQFFPFKAAINGKVTK---- 438
                                               ||.||.|..|.     |::...:..|
Zfish   397 VQDLCGWKIRSLACGKSSIIVAADDSTISWGPSPTFGELGYGDNKP-----KSSTTAQEVKTLDG 456

  Fly   439 -----VAYGVDHTIALCK 451
                 |..|..|::.:.:
Zfish   457 VYSEQVVMGYSHSLVIAR 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826	10/68 (15%)
		RCC1_2	159..188	CDD:290274	6/28 (21%)
		RCC1	175..233	CDD:278826	14/57 (25%)
		RCC1_2	220..249	CDD:290274	10/28 (36%)
		RCC1	236..286	CDD:278826	14/49 (29%)
		RCC1	290..341	CDD:278826	21/72 (29%)
		RCC1	345..395	CDD:278826	15/49 (31%)
		RCC1_2	386..414	CDD:290274	9/73 (12%)
		RCC1	402..449	CDD:278826	16/101 (16%)
rcc2	NP_998341.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56		13/52 (25%)
		RCC1 1	76..138		17/107 (16%)
		RCC1_2	121..154	CDD:290274	11/68 (16%)
		RCC1 2	141..192		15/59 (25%)
		RCC1	141..190	CDD:278826	14/57 (25%)
		RCC1	193..242	CDD:278826	14/49 (29%)
		RCC1 3	194..244		14/50 (28%)
		RCC1	245..318	CDD:278826	21/73 (29%)
		RCC1 4	246..320		22/74 (30%)
		Required for interaction with RAC1. /evidence=ECO:0000250\|UniProtKB:Q9P258	291..298		3/7 (43%)
		RCC1 5	321..374		17/56 (30%)
		RCC1	323..372	CDD:278826	15/52 (29%)
		RCC1 6	376..420		5/43 (12%)
		RCC1 7	421..474		11/57 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910