DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3862 and Als2

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster

Alignment Length:	313	Identity:	71/313 - (22%)
Similarity:	113/313 - (36%)	Gaps:	85/313 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VYVWGFQETGALGLQTNVKKAKERYTEMVHHPTRLQFSNNNEITDVAAGYGFTVYAVNRDDGETL 110
            |:|....||..:|....|.||:::...|     || :....|:.|:|||....|..|
  Fly   150 VFVGASGETYVMGSCGEVFKAEQQPRHM-----RL-YEEGKELLDLAAGNEHFVMLV-------- 200

  Fly   111 FGSGLN-TDSQLGFQVKGNPNDPANLDVIIYPTAIKLPRVQGETDEDMRVKSMSAGRA------- 167
              :..| .|..|...|.....:|                    .||...|||:|:|.:
  Fly   201 --APYNLADDALQLSVASAKEEP--------------------EDERASVKSISSGHSERSVAAN 243

  Fly   168 --HL------VVLTQNGTIFTLGNNSYGQCGRSIIEEERYSKSALIHRISQEDICGKEDEVVQVE 224
              ||      ::.||   :||.|.::.|..|..     .:.:.|.:.|:.:.|..|    |..:.
  Fly   244 TRHLLHQGYALLHTQ---LFTFGASNNGLLGSG-----DHIRRANVMRLQKLDSMG----VCSIA 296

  Fly   225 CGQDHSMFLTKKGRIYTCGWGADGQTGQGNYHTAGQITLIGG----DVEKEKIVRLSCSSDCVLA 285
            .|.:|::..|..||:|..|.....|.|: :..:..:||:...    .:|:...:..:|.....|.
  Fly   297 AGLEHTVARTLDGRLYHWGLNNHSQLGE-DVSSPMEITITENTAALPIEQNSALEATCGDYHTLL 360

  Fly   286 LNEAGDAFG----------WGNSEYGQLDDSELAETQINI--PRALKLTKSIG 326
            ||.:|....          ..:|.|.|    .|.:.|:..  ||.|:|....|
  Fly   361 LNASGQIHSLQPAPPMRHLQQSSTYAQ----TLLQLQLGAAWPRQLRLLMCSG 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826	16/52 (31%)
		RCC1_2	159..188	CDD:290274	12/43 (28%)
		RCC1	175..233	CDD:278826	12/57 (21%)
		RCC1_2	220..249	CDD:290274	8/28 (29%)
		RCC1	236..286	CDD:278826	11/53 (21%)
		RCC1	290..341	CDD:278826	11/49 (22%)
		RCC1	345..395	CDD:278826
		RCC1_2	386..414	CDD:290274
		RCC1	402..449	CDD:278826
Als2	NP_649347.1	RCC1	258..304	CDD:278826	13/57 (23%)
		RCC1_2	292..321	CDD:290274	8/28 (29%)
		RCC1	308..361	CDD:278826	11/53 (21%)
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900