DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG3862 and Als2

DIOPT Version :9

Sequence 1:NP_608550.1 Gene:CG3862 / 33261 FlyBaseID:FBgn0031286 Length:454 Species:Drosophila melanogaster
Sequence 2:NP_001013431.1 Gene:Als2 / 363235 RGDID:1310372 Length:1651 Species:Rattus norvegicus


Alignment Length:450 Identity:90/450 - (20%)
Similarity:162/450 - (36%) Gaps:109/450 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 KIKEYSPKTTDSHEHRVYVWGFQETGALGLQTNVKKAKERYTEMVHH-PTRLQFSNNNEITDVAA 93
            |:.|:|.|.....|.::              ..|:...|.....:|. ||....:.|:.:...|:
  Rat   345 KLSEHSVKENHEREEKL--------------PQVQPLVEEAVPDLHSPPTTSTSALNSLVVSCAS 395

  Fly    94 GYGFTVYAVNRDDGETLFGSGLNTDSQLGFQ-----VKGNPNDPANLDVIIYPTAIKLPRVQGET 153
            ..|..|.|       |.....|:....:.|.     ..|.|:..|:..    |.::|..|     
  Rat   396 AVGVRVAA-------TYEAGALSLKKVMNFYSTAPCEPGAPSGTASTG----PESLKDLR----- 444

  Fly   154 DEDMRVKSMSAGRAHLVVLTQNGTIFTLGNNSYGQCGRSIIEEE------RYSKSALIHRISQED 212
            :|.::.:|:...::..::                    .|.|||      |.|...|:.::|.. 
  Rat   445 EEQVKQESLQGKKSSSLM--------------------DIREEESEGGSRRLSLPGLLSQVSPR- 488

  Fly   213 ICGKEDEV-------VQVECGQDHSMFLTKKGRIYTCGWGADGQTGQGNYHTAGQ---ITLIGGD 267
            :..|...|       .....|:..::..:.:..::|.|.|.:||.|.|:.....|   :..:.| 
  Rat   489 LLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDG- 552

  Fly   268 VEKEKIVRLSCSSDCVLALNEAGDAFGWGNSEYGQLDDSELAETQINIPRALKLTKSIGKIKDVA 332
               ::::.|.......|||......:.||::.:|||..||...|   :||..|::...| :..||
  Rat   553 ---KEVIHLEAGGSHSLALTAKSQVYSWGSNTFGQLGHSEFPTT---VPRLSKVSSESG-VWSVA 610

  Fly   333 AGGSFCMALND-----QGLVYTWGFGILGFGPFVEQTSKPQHLLPPLFGRNDFSNETTVVSIGC- 391
            ||..:.:.|.|     .||.|:      |.....|..:.|::   |       |..||.|.:.| 
  Rat   611 AGHGYSLFLVDTEDFQPGLYYS------GRQDRAEGDTLPEN---P-------SGTTTPVLLSCS 659

  Fly   392 --GVFHMGAVNSDGDLFMWGKNRFGHLGLGHK----KDQFFPFKAAINGKVTKVAYGVDH 445
              |.........|..|.:..||..|::...|:    :.:|:...:.|..::.:....::|
  Rat   660 KLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSEIKSQILRPLLSLEH 719

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3862NP_608550.1 RCC1 43..99 CDD:278826 9/56 (16%)
RCC1_2 159..188 CDD:290274 1/28 (4%)
RCC1 175..233 CDD:278826 11/70 (16%)
RCC1_2 220..249 CDD:290274 5/35 (14%)
RCC1 236..286 CDD:278826 11/52 (21%)
RCC1 290..341 CDD:278826 16/50 (32%)
RCC1 345..395 CDD:278826 13/52 (25%)
RCC1_2 386..414 CDD:290274 7/30 (23%)
RCC1 402..449 CDD:278826 8/47 (17%)
Als2NP_001013431.1 RCC1 1 59..108
RCC1_2 93..122 CDD:290274
RCC1 2 109..167
RCC1 109..165 CDD:278826
RCC1 3 169..218
RCC1 170..216 CDD:278826
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..476 7/56 (13%)
RCC1 4 519..570 13/54 (24%)
RCC1 521..568 CDD:278826 11/50 (22%)
RCC1 5 572..621 17/52 (33%)
RCC1 573..619 CDD:278826 16/49 (33%)
RhoGEF 689..873 CDD:295373 3/30 (10%)
PH_alsin 899..1004 CDD:241423
PH 920..998 CDD:278594
COG4642 1043..1182 CDD:226989
MORN 1 1043..1065
MORN 1043..1063 CDD:280628
MORN 2 1066..1088
MORN 3 1094..1116
MORN 1094..1114 CDD:280628
MORN 4 1117..1139
MORN 5 1145..1167
COG4642 1166..>1266 CDD:226989
MORN 6 1169..1191
MORN 7 1192..1214
MORN 8 1215..1238
VPS9 1548..1647 CDD:280383
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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