Protein Alignment CG3862 and NEK8

DIOPT Version :9

• Sequence 1: NP_608550.1
• Gene: CG3862 / 33261
• FlyBaseID: FBgn0031286
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_835464.1
• Gene: NEK8 / 284086
• HGNCID: 13387
• Length: 692
• Species: Homo sapiens
• Alignment Length: 457
• Identity: 103/457 - (22%)
• Similarity: 161/457 - (35%)
• Gaps: 135/457 - (29%)

  Fly    12 SRSYTAKAKRGVLAQDKSKIKEYSPKTTDSHEHRVYVWGFQETGALGLQTNVKKAKERYTEMVHH 76
            ||:.:.:. ||:   .:..::...|....|    ||.||    |.||.
Human   288 SRTTSVRC-RGI---PRGPVRPAIPPPLSS----VYAWG----GGLGT----------------- 323

  Fly    77 PTRLQFSNNNEITDVAAGYGFTVYAVNRDDGETL------FGSGLNTDSQLGFQVKGNPNDPANL 135
            |.||... |.|:..||||.  |..|.....|..:      .|:|..:
Human   324 PLRLPML-NTEVVQVAAGR--TQKAGVTRSGRLILWEAPPLGAGGGS------------------ 367

  Fly   136 DVIIYPTAIKLPRVQG-----ETDEDMRVKSMSAGRAHLVVLTQNGTIFTLGNNSYGQCGRSIIE 195
               :.|.|::.|:.|.     |....:.:|.::.|......||..|.|.|.|:.|.|..|...:.
Human   368 ---LLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLT 429

  Fly   196 EERYSKSALIHRISQ----EDICGKEDEVVQVECGQDHSMFLTKKGRIYTCGWGADGQTGQG--N 254
            :           |||    |.:.|.  |:|||.||..|.:.|:.:..::..|.|..|:.|.|  .
Human   430 D-----------ISQPTIVEALLGY--EMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRE 481

  Fly   255 YHTAGQITLIGGDVEKEKIVRLSCSSDCVLALNEAGDAFGWGNSEYGQLDDSELAETQINIPRAL 319
            .|:..|...:....|.:::|   |..|..:.|...|.|...|::.:.:|....|:..:..:|.
Human   482 SHSCPQQVPMPPGQEAQRVV---CGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPH-- 541

  Fly   320 KLTKSIGKIKDVAAGGSFCMALNDQGLVYTWGFGILGFGPFVEQTSKPQHLLPPLFGRNDFSNET 384
                                    |.:.....|.:||..|..::         ||
Human   542 ------------------------QQVEEALSFTLLGSAPLDQE---------PL---------- 563

  Fly   385 TVVSIGCGVFHMGAVNSDGDLFMWGKNRFGHLGLGHKKDQFFPFKA-AING-KVTKVAYGVDHTI 447
              :||..|..|..||.:.||.:.:|.|:.|.||...::....|.|. .:.| |:..||.|...|:
Human   564 --LSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTV 626

  Fly   448 AL 449
            |:
Human   627 AI 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826	16/55 (29%)
		RCC1_2	159..188	CDD:290274	9/28 (32%)
		RCC1	175..233	CDD:278826	19/61 (31%)
		RCC1_2	220..249	CDD:290274	9/28 (32%)
		RCC1	236..286	CDD:278826	11/51 (22%)
		RCC1	290..341	CDD:278826	6/50 (12%)
		RCC1	345..395	CDD:278826	9/49 (18%)
		RCC1_2	386..414	CDD:290274	10/27 (37%)
		RCC1	402..449	CDD:278826	15/48 (31%)
NEK8	NP_835464.1	STKc_Nek8	3..258	CDD:270859
		RCC1	276..657	CDD:332518	103/457 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	277..301		4/16 (25%)
		RCC1 1	312..350		19/65 (29%)
		RCC1 2	410..461		20/63 (32%)
		RCC1 3	462..513		12/53 (23%)
		RCC1 4	580..631		16/49 (33%)
		RCC1 5	632..684

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010