DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and HECTD4

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001103132.4	Gene:	HECTD4 / 283450	HGNCID:	26611	Length:	4428	Species:	Homo sapiens

Alignment Length:	248	Identity:	53/248 - (21%)
Similarity:	87/248 - (35%)	Gaps:	78/248 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 YTEMVHHP-TRLQFSNNNEITDV-----AAG-YGFTVYAVNRDDGETLFGSGL-----------N 116
            |.:|:..| :....|:.|:..|:     |.| |.:|..:|.|  |.:..||||           |
Human   287 YEDMLPAPDSNTGSSSENKDADLGRCLTADGLYLYTTNSVGR--GVSKLGSGLHGTLRGFVYCRN 349

  Fly   117 TDSQLGFQVKGN----------PNDPANLDVIIYPTAIKLPRVQ---------GETDEDMRVKS- 161
            .:.:.|:...|:          .|.|.:|..:|....:::.:|.         |.|...:.:.|
Human   350 EELEPGWVAFGSGSLLHRPVSFDNKPHSLFQVIDQNTLQVCQVVPMPANHLPIGSTMSTVHLSSD 414

  Fly   162 --------------MSAGRAHLV------VLTQNGTIF-------TLGNNSYGQCGRSI------ 193
                          ....:.|.|      ::.:||...       |:.....|:..:||
Human   415 GTYFYWIWSPASLNEKTPKGHSVFMDIFELVVENGVFVANPLQERTILMRKEGESAKSINEMLLS 479

  Fly   194 -IEEERYSKSALIHRISQEDICG--KEDEVVQVECGQDHSMFLTKKGRIYTCG 243
             :...|.|.||.:..::...|..  |||:.....||....|.  :|..|||||
Human   480 RLSRYRASPSATLAALTGSTISNTLKEDQAANTSCGLPLKML--RKTPIYTCG 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826	9/35 (26%)
		RCC1_2	159..188	CDD:290274	6/56 (11%)
		RCC1	175..233	CDD:278826	17/73 (23%)
		RCC1_2	220..249	CDD:290274	9/24 (38%)
		RCC1	236..286	CDD:278826	6/8 (75%)
		RCC1	290..341	CDD:278826
		RCC1	345..395	CDD:278826
		RCC1_2	386..414	CDD:290274
		RCC1	402..449	CDD:278826
HECTD4	NP_001103132.4	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900