DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3862 and Sergef

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_006541006.1	Gene:	Sergef / 27414	MGIID:	1351630	Length:	465	Species:	Mus musculus

Alignment Length:	452	Identity:	111/452 - (24%)
Similarity:	170/452 - (37%)	Gaps:	119/452 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 GFQETGALGLQTNVKKAKERYTEMVHHPTRL-QFSNNNEITDVAAGYGFTVYAVNRDDGETLFGS 113
            |....|.|||         .:.|.|..|.:| .|.....|..|..|.|.:....   ||..||..
Mouse    22 GANSYGQLGL---------GHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVT---DGGDLFVC 74

  Fly   114 GLNTDSQLGFQVKGNPNDPANLDVIIYPTAIKLPRVQGETDEDMR-----------VKSMSAGRA 167
            |||.|.|||.                           |.|:|.:|           ::.::.|..
Mouse    75 GLNKDGQLGL---------------------------GHTEEVLRFTICKPLRGCPIRQVACGWD 112

  Fly   168 HLVVLTQNGTIFTLGNNSYGQCG-----RSIIEEERYSKSALIHRISQEDICGKEDEVVQVECGQ 227
            ..::||:.|.:.:.|:|::||.|     |..:             :.|...|.:| :||.|..|.
Mouse   113 FTIMLTEKGQVLSCGSNAFGQLGVPHGPRKCV-------------VPQAIECLRE-KVVCVAAGL 163

  Fly   228 DHSMFLTKKGRIYTCGWGADGQTGQGN----------YHTAGQITLIGGDVEKEKIVRLSCSSDC 282
            .|::..|..|.::.  ||. |....|.          :.||.:.:.:.| :|....|.....||.
Mouse   164 RHALATTATGSVFQ--WGT-GLASSGRRLCPGQNLPLFLTAKEPSRVTG-LENSTAVCAVAGSDH 224

  Fly   283 VLALNEAGDAFGWGNSEYGQLDDSELAETQINIPRALKLTKSI---GKIKDVAAGGSFCMALNDQ 344
            ..:|.:.|:.:.||.:::||     ||...:.:|...::....   .|:..|.:|.:..:|..:.
Mouse   225 SASLTDTGELYVWGRNKHGQ-----LASRAVFLPLPQRIEAHYFQDEKVTAVWSGWTHLVAKTET 284

  Fly   345 GLVYTWG---FGILG--FGP-----FVEQTSK-----PQHLLP-PLFGRNDFSNETTVVSIGCGV 393
            |.|:|||   :|.||  ..|     .|||.|.     ||:.:| ||...      |....|.||.
Mouse   285 GKVFTWGRADYGQLGRRLEPPEAQKPVEQDSSLAFQGPQNSVPSPLHCL------TGATEISCGS 343

  Fly   394 FHMGAVNSDGDLFMWGKNRFGHLGLGHKKDQFFPFKAAI----NGKVTKVAYGVDHTIALCK 451
            .|..||..| ....||.|..|..|.|.:.:.:.|.....    ..::..|..|..|::|:|:
Mouse   344 EHNLAVIRD-KCCSWGWNEHGMCGDGTESNVWTPTPVQALPPSPSRLLLVGCGAGHSLAVCQ 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826	14/49 (29%)
		RCC1_2	159..188	CDD:290274	6/28 (21%)
		RCC1	175..233	CDD:278826	15/62 (24%)
		RCC1_2	220..249	CDD:290274	9/28 (32%)
		RCC1	236..286	CDD:278826	12/59 (20%)
		RCC1	290..341	CDD:278826	11/53 (21%)
		RCC1	345..395	CDD:278826	22/65 (34%)
		RCC1_2	386..414	CDD:290274	10/27 (37%)
		RCC1	402..449	CDD:278826	11/50 (22%)
Sergef	XP_006541006.1	ATS1	22..370	CDD:227511	105/416 (25%)
Sergef	XP_006541006.1	RCC1	356..402	CDD:366085	10/45 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910