DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and Hectd4

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_006530414.1	Gene:	Hectd4 / 269700	MGIID:	3647820	Length:	4525	Species:	Mus musculus

Alignment Length:	320	Identity:	66/320 - (20%)
Similarity:	107/320 - (33%)	Gaps:	105/320 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 YTEMVHHP-TRLQFSNNNEITDV-----AAG-YGFTVYAVNRDDGETLFGSGL-----------N 116
            |.:|:..| :....|:.|:..|:     |.| |.:|..:..|  |.:..||||           |
Mouse   381 YEDMLPAPDSNTGSSSENKDADLGRCLTADGHYLYTTNSAGR--GVSKLGSGLHGTLRGFVYCRN 443

  Fly   117 TDSQLGFQVKGN----------PNDPANLDVIIYPTAIKL---------PRVQGETDEDMRVKS- 161
            .:.:.|:...||          .|.|.:|..:|....:::         |...|.|...:.:.|
Mouse   444 EELEPGWVAYGNGHLLHRPVSFDNKPHSLFQVIDQNTLQVCQTVPMPASPLPVGSTMSTVHLSSD 508

  Fly   162 --------------MSAGRAHLV------VLTQNGTIF-------TLGNNSYGQCGRSI------ 193
                          ....:.|.|      ::.:||...       |:.....|:..:||
Mouse   509 GTYFYWIWSPASLNEKTPKGHSVFMDIFELVVENGVFVANPLQERTILMRKEGESAKSINEMLLS 573

  Fly   194 -IEEERYSKSALIHRISQEDICG--KEDEVVQVECGQDHSMFLTKKGRIYTCGW---------GA 246
             :...|.|.||.:..::...|..  |||:.....||....|.  :|..:||||.         |.
Mouse   574 RLSRYRASPSATLAALTGSTISNTLKEDQAANTSCGLPLKML--RKTPMYTCGTYLVMLVPPPGG 636

  Fly   247 DGQTGQGNYHTAGQITLIGGDVEKEKIVRLSCS-----SDCVLA-----LNEAGDAFGWG 296
            .|        ::...:|.||......:..|:.|     ||...|     ::.||.:.|.|
Mouse   637 SG--------SSATRSLFGGTSGLSSLKILASSLVYNISDGQFASRADLIDAAGSSLGRG 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826	9/35 (26%)
		RCC1_2	159..188	CDD:290274	6/56 (11%)
		RCC1	175..233	CDD:278826	17/73 (23%)
		RCC1_2	220..249	CDD:290274	9/37 (24%)
		RCC1	236..286	CDD:278826	15/68 (22%)
		RCC1	290..341	CDD:278826	3/7 (43%)
		RCC1	345..395	CDD:278826
		RCC1_2	386..414	CDD:290274
		RCC1	402..449	CDD:278826
Hectd4	XP_006530414.1	CCDC154	149..>233	CDD:373856
		SPRY_HECT_like	2507..2662	CDD:293970
		HECTc	4127..4520	CDD:391658
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900