DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3862 and HERC4

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_011537894.1	Gene:	HERC4 / 26091	HGNCID:	24521	Length:	1081	Species:	Homo sapiens

Alignment Length:	351	Identity:	92/351 - (26%)
Similarity:	140/351 - (39%)	Gaps:	86/351 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 GETDEDM-------------RVKSMSAGRAHLVVLTQNGTIFTLGNNSYGQCGRSIIEEERYSKS 202
            |..||::             ||:.:..|..|.|.:..:||::|.|.|..||.|.   |:.|....
Human    15 GGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGH---EKSRKKPE 76

  Fly   203 ALIHRISQEDICGKEDEVVQVECGQDHSMFLTKKGRIYTCGWGADGQTGQGNYHTAGQITLIGGD 267
            .::...:|        .:|.|.||:.|::.|..||::|..|..:|||.|           |:|.:
Human    77 QVVALDAQ--------NIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG-----------LVGSE 122

  Fly   268 -----------------------------------VEKEKIVRLSCSSDCVLALNEAGDAFGWGN 297
                                               :...:||:::|.....|||::|.:.|.||.
Human   123 ECIRVPSCFPKIMCVDSLVRICSGLSYGRIRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQ 187

  Fly   298 SEYGQLDDSELAETQINIPRALKLTKSIGKIKDVAAGGSFCMALNDQGLVYTWG---FGILGFGP 359
            ::||||......:.|.: |:.||....| ....|||||:....|...|.::.||   ||.||...
Human   188 NKYGQLGLGTDCKKQTS-PQLLKSLLGI-PFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLND 250

  Fly   360 FVEQTSKPQHLLPPLFGRNDFSNETTVVSIGCGVFHMGAVNSDGDLFMWGKNRFGHLGLGHKKDQ 424
              |......:||..|       ....:|.|.||..|..|:..:|.:|.:|...:|.||......:
Human   251 --ENDRYVPNLLKSL-------RSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHE 306

  Fly   425 FFPFKA--AINGKVTKVAYGVDHTIA 448
            ..|.|.  .:...||::|.|..||.|
Human   307 INPRKVFELMGSIVTEIACGRQHTSA 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826
		RCC1_2	159..188	CDD:290274	9/28 (32%)
		RCC1	175..233	CDD:278826	16/57 (28%)
		RCC1_2	220..249	CDD:290274	11/28 (39%)
		RCC1	236..286	CDD:278826	14/84 (17%)
		RCC1	290..341	CDD:278826	17/50 (34%)
		RCC1	345..395	CDD:278826	15/52 (29%)
		RCC1_2	386..414	CDD:290274	9/27 (33%)
		RCC1	402..449	CDD:278826	15/49 (31%)
HERC4	XP_011537894.1	RCC1	2..368	CDD:332518	92/351 (26%)
HERC4	XP_011537894.1	HECTc	733..1079	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920