DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and Rpgr

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001171421.1	Gene:	Rpgr / 19893	MGIID:	1344037	Length:	1039	Species:	Mus musculus

Alignment Length:	356	Identity:	87/356 - (24%)
Similarity:	145/356 - (40%)	Gaps:	93/356 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 MSAGRAHLVVLTQNGTIFTLGNNSYGQCGRSIIEEERYSKSALIHRISQEDICGKEDEVVQVECG 226
            :|.|..|..::|.|..::..|:|::||.|..       ||:|:|.....:.:  |.::|....||
Mouse    78 LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLG-------SKAAIIKPTCIKAL--KPEKVKLAACG 133

  Fly   227 QDHSMFLTKKGRIYTCGWGADGQTGQGN------YHTAGQITLIGGDVEKEKIVRLSCSSDCVLA 285
            ::|::..|..|.:|..|...:||.|.|:      :|   ||...   ...:.|.:||..::...|
Mouse   134 RNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFH---QIVFF---TPADTIKQLSAGANTSAA 192

  Fly   286 LNEAGDAFGWGNSEYGQ--LDDSELAETQINIPRALKLTKSIG---------------------- 326
            |.|.|..|.||::..||  |:|    ::.:.||..:.:.|.|.
Mouse   193 LTEDGKLFMWGDNSEGQIGLED----KSNVCIPHEVTVGKPISWISCGYYHSAFVTMDGELYTFG 253

  Fly   327 ----------------------------KIKDVAAGGSFCMALNDQGLVYTWG---FGILGFGPF 360
                                        ::..||.||...:.|.:: :||.:|   ||.||.|.|
Mouse   254 EPENGKLGLPNELLMNHRSPQRVLGIPERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQLGLGTF 317

  Fly   361 VEQTSKPQHLLPPLFGRNDFSNETTVVSIGCGVFHMGAVNSDGDLFMWGKNRFGHLGLGHKK--D 423
            :.:||:|:.:        :...:..:..|.||..|...:...|.|:.:|..|.|.||||.:.  :
Mouse   318 LFETSEPKII--------ERIKDQKICHISCGENHTALMTELGLLYTFGDGRHGKLGLGMENFTN 374

  Fly   424 QFFPFKAA--INGKVTKVAYGVDHTIALCKP 452
            ||||...:  :...|..:|.|..|.:....|
Mouse   375 QFFPTLCSNFLRFAVQLIACGGCHMLVFATP 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826
		RCC1_2	159..188	CDD:290274	7/25 (28%)
		RCC1	175..233	CDD:278826	15/57 (26%)
		RCC1_2	220..249	CDD:290274	8/28 (29%)
		RCC1	236..286	CDD:278826	13/55 (24%)
		RCC1	290..341	CDD:278826	16/102 (16%)
		RCC1	345..395	CDD:278826	15/52 (29%)
		RCC1_2	386..414	CDD:290274	8/27 (30%)
		RCC1	402..449	CDD:278826	17/50 (34%)
Rpgr	NP_001171421.1	RCC1_2	78..104	CDD:290274	7/25 (28%)
		RCC1	93..139	CDD:278826	14/54 (26%)
		RCC1	144..193	CDD:278826	13/54 (24%)
		RCC1_2	180..209	CDD:290274	10/28 (36%)
		RCC1	196..243	CDD:278826	12/50 (24%)
		RCC1	246..296	CDD:278826	4/49 (8%)
		RCC1	301..348	CDD:278826	16/54 (30%)
		RCC1	352..398	CDD:278826	16/45 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910