DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and ran-3

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_495753.1	Gene:	ran-3 / 174332	WormBaseID:	WBGene00004304	Length:	569	Species:	Caenorhabditis elegans

Alignment Length:	362	Identity:	95/362 - (26%)
Similarity:	145/362 - (40%)	Gaps:	75/362 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 TAIKLPR-VQGETDEDMRVKSMSAGRAHLVVLTQNGTIFTLGNNSYGQCGRSIIEEE----RYSK 201
            |..|.|| |....:|.::.....||..|..|||..|.::..|.|..|......:|:|    .::|
Worm   169 TTTKKPRKVDIFEEEGLKPLQAVAGGVHSAVLTSEGEVYMCGINEKGTVPAEGVEKEGSTDEFAK 233

  Fly   202 SALIHRISQEDICGKEDEVVQVECGQDHSMFLTKKGRIYTCGWGADGQTGQGN------YHTAGQ 260
            ...     :||| .||.::|.:..|...:..||.:|.:  ..|| :.:...||      .|...:
Worm   234 VKF-----EEDI-EKEGKIVMLAAGASFTAALTDQGSV--IAWG-NLRNSNGNVDVHPLLHKMQE 289

  Fly   261 ITLIGGDVEKEKIVRLSCSSDCVLALNEAGDAFGWGNSEYGQLDDSELAET------------QI 313
            ..::.....|.|||:::...:.::.|:|.|....:|:.|.|||..|...:|            .:
Worm   290 APVVIVHQAKRKIVKIAAGENHLVMLDEKGCLLTFGDGEMGQLGRSSRTKTIRSKYMCDESGDHL 354

  Fly   314 NIPRALKLTKSIGKI-----KDVAAGGSFCMALNDQGLVYTWG---FGILGF-------GPFVEQ 363
            .:|...   |..||.     |:|.|.|.:.:...:.|..|.:|   :..||.       |...:.
Worm   355 LVPLRF---KHKGKFFDVVAKNVFASGFWTIVHGEDGKYYAFGLNNYAQLGIKVDEADVGQDGQD 416

  Fly   364 TSKPQHLLP---PLFGRNDFSNETTVVSIGCGVFHMGAVNSDGDLFMWGKNRFGHLGLGH---KK 422
            ..:.:..||   |.||.     |.|.|:|. ||.|:..:.|||.:|..|||....||||:   |.
Worm   417 NRELRVFLPAEAPAFGA-----ERTFVNIE-GVQHVVILGSDGKVFAMGKNTDNALGLGNWTGKD 475

  Fly   423 D---------QFFPFKAAING----KVTKVAYGVDHT 446
            |         |...|.:.|.|    ..|.:|:..|.|
Worm   476 DQQHWLYDTIQEIEFDSKIVGVSAKLATSIAWSEDGT 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826
		RCC1_2	159..188	CDD:290274	9/28 (32%)
		RCC1	175..233	CDD:278826	14/61 (23%)
		RCC1_2	220..249	CDD:290274	7/28 (25%)
		RCC1	236..286	CDD:278826	10/55 (18%)
		RCC1	290..341	CDD:278826	16/67 (24%)
		RCC1	345..395	CDD:278826	17/62 (27%)
		RCC1_2	386..414	CDD:290274	12/27 (44%)
		RCC1	402..449	CDD:278826	20/61 (33%)
ran-3	NP_495753.1	ATS1	163..569	CDD:227511	95/362 (26%)
		RCC1_2	189..215	CDD:290274	9/25 (36%)
		RCC1_2	246..276	CDD:290274	7/32 (22%)
		RCC1_2	302..331	CDD:290274	7/28 (25%)
		RCC1	510..565	CDD:278826	2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910