DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and W09G3.7

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001021671.2	Gene:	W09G3.7 / 173245	WormBaseID:	WBGene00012370	Length:	404	Species:	Caenorhabditis elegans

Alignment Length:	426	Identity:	138/426 - (32%)
Similarity:	210/426 - (49%)	Gaps:	53/426 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KTTDSHEHRVYVWGFQETGALGLQTNVKKAKERYTEMVHHPTRLQFSNNNEITDVAAGYGFTVYA 101
            ||..:.:..||..|...:|||.:...|..:.:........|.|:.:.|...|..:::|:||:::|
Worm    17 KTRKNVDCAVYGCGLSASGALAIPKLVANSDDVTAGEARFPKRIAYFNTKSIKFISSGFGFSLFA 81

  Fly   102 -VNRDDGETLFGSGLNTDSQLGFQVKGNPNDPANLDVIIYPTAIKLPRVQGETDEDMRVKSMSAG 165
             .||     |:|:|:|...|:|.|:   .|.....|..|....|.:|     .||   :..:|:|
Worm    82 SKNR-----LYGAGINNRFQIGGQL---TNINKYQDYYISAKKINIP-----GDE---ILEISSG 130

  Fly   166 RAHLVVLTQNGTIFTLGNNSYGQCGRSIIEEERYSKSALIHRISQEDICGKEDE----------- 219
            |||.::.|..| :|.:|:|::|||||: .|...|             :.|.|:.
Worm   131 RAHSLIRTNLG-VFAIGDNNFGQCGRN-PENMDY-------------VVGSEESPLLPLSFPTSE 180

  Fly   220 -VVQVECGQDHSMFLTKKGRIYTCGWGADGQTGQGNYHTAGQITLIGGDVEKEKIVRLSCSSDCV 283
             ::.:.|..|.|..:...|.:::.|...|||.|...|....:...:.||||..||.::|.|:|.:
Worm   181 PIISIHCSMDTSFVVDSSGAVFSFGLNEDGQCGNEAYGIQWEPAKVRGDVEGSKIQKVSGSTDTL 245

  Fly   284 LALNEAGDAFGWGNSEYGQLDDSELAETQINIPRALKLTKSIGKIKDVAAGGSFCMALNDQGLVY 348
            ||.:|.|:.|.||.:||||...: ..|.|:|..|  .:..|:|.|..|.:..|..:|.|.:|.|:
Worm   246 LACSENGEIFIWGQTEYGQAAGA-TDEIQLNTSR--HVANSLGPIICVDSTQSSVVARNSRGNVF 307

  Fly   349 TWGFGILGFGPFVEQTSKPQHLLPPLFGRNDFSNETTVVSIGCGVFHMGAVNSDGDLFMWGKNRF 413
            .||.|:||.||..|....|..:..|||      :...|.|:..|...|.|:|.||.||:||:||:
Worm   308 VWGVGVLGMGPEAESLKTPTQMDQPLF------DGKMVTSVSAGNSCMSAINEDGRLFIWGENRY 366

  Fly   414 GHLGLGHKKDQFFPFKAAINGKVTKVAYGVDHTIAL 449
            ..|||||:|.|.||::..:.|.|.|.|.|.||::.|
Worm   367 SSLGLGHQKRQLFPYQLFLPGDVRKAALGPDHSLFL 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826	14/55 (25%)
		RCC1_2	159..188	CDD:290274	10/28 (36%)
		RCC1	175..233	CDD:278826	16/69 (23%)
		RCC1_2	220..249	CDD:290274	6/28 (21%)
		RCC1	236..286	CDD:278826	17/49 (35%)
		RCC1	290..341	CDD:278826	17/50 (34%)
		RCC1	345..395	CDD:278826	17/49 (35%)
		RCC1_2	386..414	CDD:290274	14/27 (52%)
		RCC1	402..449	CDD:278826	24/46 (52%)
W09G3.7	NP_001021671.2	ATS1	<108..347	CDD:227511	83/270 (31%)
		RCC1	142..195	CDD:278826	15/66 (23%)
		RCC1	198..239	CDD:278826	13/40 (33%)
		RCC1	355..402	CDD:278826	24/46 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166308
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36477
Inparanoid	1	1.050	205	1.000	Inparanoid score	I2436
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45758
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0007486
OrthoInspector	1	1.000	-	-		oto19777
orthoMCL	1	0.900	-	-		OOG6_106330
Panther	1	1.100	-	-	LDO	PTHR46337
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3252
SonicParanoid	1	1.000	-	-		X5611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.940