DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and herc-1

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_490834.1	Gene:	herc-1 / 171700	WormBaseID:	WBGene00021685	Length:	1019	Species:	Caenorhabditis elegans

Alignment Length:	366	Identity:	104/366 - (28%)
Similarity:	155/366 - (42%)	Gaps:	74/366 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 LFGSGLNTDSQLGFQVKGNPNDPANLDVIIYPTAIKLP-RVQGETDEDM---RVKSMSAGRAHLV 170
            |.|.|...:.|||              |.:..:.|::| |:.| ...||   .|.|::.|..|.|
Worm     5 LLGCGHTGEGQLG--------------VRLSESTIQVPERIIG-APNDMDGTAVTSVTCGEQHTV 54

  Fly   171 VLTQNGTIFTLGNNSYGQCGRSIIEEERYSKSALIHRISQEDICGKEDEVVQVECGQDHSMFLTK 235
            .||::|.::::|:|..||.||....|..:|    |:.:|..    ...:::|:..|:.|::.:|.
Worm    55 FLTKDGKMWSVGSNMDGQLGRGSRTEGSFS----IYPVSWT----SSAKIIQISAGRSHTVSVTD 111

  Fly   236 KGRIYTCGWGADGQTG-------QGNYHTAGQITLIGGDVEKEKIVRLSCSSDCVLALNEAGDAF 293
            .||::..|....||.|       ||......:|         ..||:::..|:..:||:|.|..|
Worm   112 DGRVFAWGSNEHGQLGMESKFTWQGTPRRVQEI---------NDIVQVASGSNHCIALDEGGRVF 167

  Fly   294 GWGNSEYGQ-LDDSELAETQINIPRALKLTKSIGKIKDVAAGGSFCMALNDQGLVYTWG---FGI 354
            .||....|: :...|..|....:|           |..|.||...|:||:..|.|:|||   .|.
Worm   168 VWGEQADGRCIHRPEPVEQLSGVP-----------IVRVLAGARHCLALSASGAVFTWGQNNSGE 221

  Fly   355 LGFGPFVEQTSKPQHLLPPLFGRNDFSNETTVVSIGCGVFHMGAVNSDGDLFMWGKNRFGHLGLG 419
            ||......||| .||:        ...:...||...||..|...:...|..|.:|.:..|..|.|
Worm   222 LGIDDLRPQTS-VQHV--------HQMDGLGVVEAACGDNHTVLLTHCGRTFSFGSDALGQCGFG 277

  Fly   420 HKKDQFFPFKAA---INGKVTKVAYGVDHTIALCK----PF 453
            .|.::.....|.   |...||::|.|..||||:||    ||
Worm   278 KKVEKRTNPTAVSDLIGSHVTRIAAGACHTIAICKGAPYPF 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826
		RCC1_2	159..188	CDD:290274	10/28 (36%)
		RCC1	175..233	CDD:278826	14/57 (25%)
		RCC1_2	220..249	CDD:290274	7/28 (25%)
		RCC1	236..286	CDD:278826	12/56 (21%)
		RCC1	290..341	CDD:278826	13/51 (25%)
		RCC1	345..395	CDD:278826	17/52 (33%)
		RCC1_2	386..414	CDD:290274	8/27 (30%)
		RCC1	402..449	CDD:278826	16/49 (33%)
herc-1	NP_490834.1	ATS1	2..359	CDD:227511	104/366 (28%)
herc-1	NP_490834.1	HECTc	667..1016	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920