DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and Nek8

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_006532246.1	Gene:	Nek8 / 140859	MGIID:	1890646	Length:	702	Species:	Mus musculus

Alignment Length:	443	Identity:	107/443 - (24%)
Similarity:	163/443 - (36%)	Gaps:	110/443 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SRSYTAKAKRGVLAQDKSKIKEYSPKTTDSHEHRVYVWGFQETGALGLQTNVKKAKERYTEMVHH 76
            ||:.:|:. |||   .:..::...|....|    ||.||    |.|.                 .
Mouse   294 SRATSARC-RGV---PRGPVRPAIPPPLSS----VYAWG----GGLS-----------------S 329

  Fly    77 PTRLQFSNNNEITDVAAGYGFTVYAVNRDDGETL------FGSGLNTDSQLGFQVKGNPNDPANL 135
            |.||... |.|:..||||.  |..|.....|..:      .|:|..|
Mouse   330 PLRLPML-NTEVVQVAAGR--TQKAGVTRSGRLILWEAPPLGAGGGT------------------ 373

  Fly   136 DVIIYPTAIKLPRVQG-----ETDEDMRVKSMSAGRAHLVVLTQNGTIFTLGNNSYGQCGRSIIE 195
               :.|.|::||:.|.     |....:.:|.::.|......||..|.|.|.|:.|.|..|...:.
Mouse   374 ---LLPGAVELPQPQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLT 435

  Fly   196 EERYSKSALIHRISQ----EDICGKEDEVVQVECGQDHSMFLTKKGRIYTCGWGADGQTGQG--N 254
            :           |||    |.:.|.  |:|||.||..|.:.|:..|.::..|.|..|:.|.|  .
Mouse   436 D-----------ISQPTIVEALLGY--EMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRE 487

  Fly   255 YHTAGQITLIGGDVEKEKIVRLSCSSDCVLALNEAGDAFGWGNSEYGQ--LDDSELAETQI---N 314
            .|...|...:....|.:::|   |..|..:.|...|.....|::.:.:  ||...|.|..:   .
Mouse   488 SHNCPQQVPVAPGQEAQRVV---CGIDSSMILTSPGRVLACGSNRFNKLGLDHLSLDEEPVPYQQ 549

  Fly   315 IPRALKLTKSIGK-------IKDVAAGGSFCMALNDQGLVYTWGFGILG-FGPFVEQTSKPQHLL 371
            :..||..| .:|.       :..|..|.:...|:...|..||:|....| .|....:.|:....:
Mouse   550 VEEALSFT-PLGSAPLDQEPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRV 613

  Fly   372 PPLFGRNDFSNETTVVSIGCGVFHMGAVNSDGDLFMWGKNRFGHLGLGHKKDQ 424
            ..|.|       ..:|.:.||.....||.::|:::.|||...|.||   ::|:
Mouse   614 QGLEG-------IKMVMVACGDAFTVAVGAEGEVYSWGKGTRGRLG---RRDE 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826	15/55 (27%)
		RCC1_2	159..188	CDD:290274	9/28 (32%)
		RCC1	175..233	CDD:278826	19/61 (31%)
		RCC1_2	220..249	CDD:290274	10/28 (36%)
		RCC1	236..286	CDD:278826	12/51 (24%)
		RCC1	290..341	CDD:278826	12/62 (19%)
		RCC1	345..395	CDD:278826	12/50 (24%)
		RCC1_2	386..414	CDD:290274	9/27 (33%)
		RCC1	402..449	CDD:278826	8/23 (35%)
Nek8	XP_006532246.1	STKc_Nek8	3..258	CDD:270859
Nek8	XP_006532246.1	ATS1	318..663	CDD:227511	100/415 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010